Jan 1, 2018 · Pyruvate dehydrogenase kinase isoenzyme 4 (PDK4) plays key role in glucose metabolism via regulating the activity of pyruvate dehydrogenase complex (PDC). Here, we …

Jan 1, 2018 · In the current study, we identified the role of PDK4 contributed to the pathogenesis of NAFLD and NASH via regulating hepatic lipid and glucose metabolism. Pdk4 deficiency can …

Mar 4, 2022 · Elafibranor-mediated upregulation of ANGPTL4, PDK4, and PLIN2 is predicted to induce steatosis functions in in vitro NASH models, contrarily to observed downregulation in …

Feb 24, 2022 · PDK4 plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits (PDHA1 and …

In conclusion, our data indicated that PDK4 potentially contributes to the hepatic steatosis in NASH via regulating several signaling pathway and PDK4 may be a new therapeutic strategy …

May 7, 2024 · Immunoblotting revealed a significant reduction in the PPARα target gene PDK4 and in PCK1 in mouse NASH samples compared with chow controls (Figure 4O). To extend …

Nov 1, 2017 · Hepatic PDK4 levels were highly induced in human patients with NASH and MCD diet fed mice, as well as in hepatocytes treated with oleic acid. The glucose and lipid …

miR-145a-5p could downregulate the nuclear receptor Nr4a2 to inhibit the expression of NASH-associated genes. We highlight the pathological role of the miR-145a-5p/Nr4a2 axis in …

Jan 1, 2018 · Pdk4 deficiency can ameliorated the hepatic steatosis in MCD induced NASH mice via several signaling pathway. This newly identified role of PDK4 provides a novel clue to the …

We now show that pyruvate dehydrogenase kinase 4 (PDK4), plays a role in the regulation of mitochondrial dynamics. PDK4 promotes mitochondrial fission via phosphorylation of Septin 2 …