Apr 1, 2023 · PDK1-catalyzed PDHA pSer 232 contributed to metabolic reprogramming in PMOP. PDHA pSer 232 level highly differs between normal and PMOP-conditioned osteoclasts. PDK1 …

PDH kinases (PDK1-4) regulate PDH activity by phosphorylating PDHA1 at three individual serine (Ser, S) residues (S293, S300 and S232) . PDK1 is frequently increased in cancer cells and …

Jan 15, 2018 · Here, we found that genetic and pharmacological inactivation of pyruvate dehydrogenase A1 (PDHA1), a subunit of the pyruvate dehydrogenase complex (PDC), …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

PDK1 is frequently upregulated in primary nasopharyngeal carcinoma and may serve as a prognostic marker. A new function for PDK1 in metabolic reprogramming, which could be used …

Mar 1, 2022 · Here, we show that Pyruvate dehydrogenase kinase 1 (PDK1) acts as a targetable determinant of different metabolic states in acute myeloid leukemia (AML). PDK1 low AMLs …

Jan 8, 2022 · Pyruvate dehydrogenase kinase 1 (PDK1) is a Ser/Thr kinase that inactivates mitochondrial pyruvate dehydrogenase (PDH), leading to switch of glucose metabolism from …

PDK1 phosphorylates pyruvate dehydrogenase (PDH) to inhibit its activity, thereby reducing the level pyruvic acid in the tricarboxylic acid cycle, which affects the rates of OXPHOS 8.

Nov 7, 2023 · Research showed that Aβ-resistant nerve cells displayed increased PDK1 expression, enhanced lactate dehydrogenase A (LDHA) activity and reduced mitochondrial …

Here we show that PDK1 regulates cardiomyocyte fuel preference by mediating triacylglycerol turnover in differentiated H9c2 myoblasts using lentiviral shRNA to knockdown Pdk1. …