PDK1 selectively phosphorylates Thr(308) on Akt and contributes …
In this study, we tested two pharmacological inhibitors of PDK1, BX795 and BX912, to assess the role of Thr308 phosphorylation on Akt. PAR4-induced phosphorylation of Akt onThr308 was …
PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 …
Aug 8, 2016 · Castel et al. show that PDK1 activates SGK1 to phosphorylate and inhibit TSC2, contributing to maintenance of mTORC1 activity and resistance of PIK3CA-mutant cancer …
PDK1-AKT signaling pathway regulates the expression and
Jun 1, 2020 · Key findings: HCN1 expression and AKT phosphorylation at the Thr308 site were significantly decreased in atrial myocytes after PDK1 knockout or inhibition; in contrast, HCN2 …
Activation of the essential kinase PDK1 by phosphoinositide …
Apr 6, 2022 · We propose a model of lipid-dependent PDK1 activation in which PH domain-mediated autoinhibition is relieved by PIP 3 or PI (3,4)P 2 binding, leading to strongly …
S6K1-mediated phosphorylation of PDK1 impairs AKT kinase
Mar 22, 2022 · Here we report that ribosomal protein S6 kinase beta 1 (S6K1), a member of AGC kinases and downstream target of mechanistic target of rapamycin complex 1 (mTORC1), …
CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and …
We demonstrate that (1) PDK1 is a putative downstream kinase of CDK1 as PDK1 contains an evolutionarily conserved CDK1 consensus phosphorylation site at Thr354; (2) CDK1 interacts …
Scaffolding function of PAK in the PDK1–Akt pathway
Oct 19, 2008 · Here we show that Rac1 stimulates a second, kinase-independent function of PAK1. The PAK1 kinase domain serves as a scaffold to facilitate Akt stimulation by PDK1 and …
Proliferative and Antiapoptotic Signaling Stimulated by Nuclear ...
Nov 6, 2012 · We report that nuclear PDK1 promoted cell proliferation by suppressing FOXO3A-dependent transcription of the gene encoding p27 Kip1 (an inhibitor of cell cycle progression), …
PDK1 selectively phosphorylates Thr(308) on Akt and …
Mar 3, 2014 · In this study, we tested two pharmacological inhibitors of PDK1, BX795 and BX912, to assess the role of Thr308 phosphorylation on Akt. PAR4-induced phosphorylation of Akt on …
PDK1 regulates B cell differentiation and homeostasis
Jul 1, 2014 · Here we focus on the B cell-specific role of the Ser/Thr kinase phosphoinositide-dependent kinase 1 (PDK1), a pivotal downstream effector of PI3K signaling that is required …