In mammals, PDK1-PDK4 are expressed in tissue- or cell-type-specific ways by four different genes, which are responsible for tissue- or cell-specific regulation of PDC. They are mainly …

Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. [5] [6] It codes for an isozyme of pyruvate …

Pyruvate dehydrogenase kinase (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate …

Oct 30, 2023 · We find that lactate promotes reactive oxygen species production via NOX1 to drive the senescence-associated secretory phenotype, whereas PDK4 suppression reduces …

In humans, there have been four isozymes of Pyruvate Dehydrogenase Kinase that have been shown to phosphorylate these three sites: PDK1, PDK2, PDK3, and PDK4. PDK1 is the only …

Mar 7, 2024 · Phosphorylation of PDC is facilitated by four isoforms of pyruvate dehydrogenase kinase (PDK1–4), which exhibit approximately 70% homology in human 7. These …

Mar 1, 2022 · Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 …

Pyruvate dehydrogenase kinase (also called PDC kinase or PDK) is a kinase that regulates glucose metabolism by switching off PDC. Four isoforms of PDKs with tissue specific activities …

Jul 4, 2023 · Methods and results: Gene profiling of human atherosclerotic plaques revealed a strong correlation between PDK1 and PDK4 transcript levels and the expression of pro …

Dec 25, 2024 · PDK4 (Pyruvate Dehydrogenase Kinase 4) is a Protein Coding gene. Diseases associated with PDK4 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …