Activation of the essential kinase PDK1 by phosphoinositide …
Apr 6, 2022 · In this study, we have elucidated the mechanism of phosphoinositide-driven PDK1 auto-activation. We show that PDK1 trans-autophosphorylation is mediated by a PIP3 …
Hypoxia-induced acetylation of PAK1 enhances autophagy and …
Mar 18, 2020 · Mechanistically, hypoxia induces ELP3-mediated PAK1 acetylation at K420, which suppresses the dimerization of PAK1 and enhances its activity, thereby leading to subsequent …
A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective …
Feb 6, 2023 · In a preliminary study, we synthesized a series of new PDK1/MEK dual inhibitors. Antitumor activity screening showed that Compound YZT exerts a strong inhibitory action in …
Hypoxia-induced acetylation of PAK1 enhances autophagy and
Mechanistically, hypoxia induces ELP3-mediated PAK1 acetylation at K420, which suppresses the dimerization of PAK1 and enhances its activity, thereby leading to subsequent PAK1 …
Mitochondrial ROS-derived PTEN oxidation activates PI3K
Jul 24, 2018 · In this study, we provide evidences that mtROS induce PTEN oxidation to stimulate PI3K/AKT/mTOR signaling pathway and thus promote autophagy, which is required for muscle …
P21-Activated Kinase 1: Emerging biological functions and …
PAK1 regulates autophagy via direct or indirect regulation. Acetylation of PAK1 could phosphorylate ATG5 to inhibit its ubiquitination-dependent degradation to promote autophagy. …
Targeting PDK1 with dichloroacetophenone to inhibit acute …
We found that treatment with DAP significantly inhibited cell proliferation, increased apoptosis induction and suppressed autophagy in AML cells in vitro, and inhibited tumor growth in an …
Dioscin ameliorates doxorubicin‐induced heart failure via …
Aug 14, 2023 · Besides, the effects of Dioscin on Dox-stimulated HL-1 cell apoptosis, oxidative stress, and autophagy-associated proteins Beclin1 and Atg5 were offset after co-incubation …
Disruption of Autophagic Flux and Treatment with the PDPK1 …
3-Phosphoinositide-dependent kinase 1 (PDPK1 or PDK1) functions downstream of PI3K and is crucial for the activation of Akt and many other AGC kinases 9, 10. Accumulating evidence …
A Novel PDK1/MEK Dual Inhibitor Induces Cytoprotective
Feb 6, 2023 · In a preliminary study, we synthesized a series of new PDK1/MEK dual inhibitors. Antitumor activity screening showed that Compound YZT exerts a strong inhibitory action in …