
Pyruvate dehydrogenase kinases (PDKs): an overview toward …
Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation.
PDK1 pyruvate dehydrogenase kinase 1 [ Homo sapiens (human) ]
Jan 4, 2025 · Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.
ProdataKey vs DMP X1: A Cloud-Access Comparison
Apr 1, 2024 · ProdataKey (PDK) and DMP X1 are two important contenders in cloud-based access, each bringing a unique set of features and functionalities to the table. This article will explore their differences, delivering insight to guide businesses in selecting their ideal solution.
PDK1 Gene - GeneCards | PDK1 Protein | PDK1 Antibody
Dec 25, 2024 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease. Among its related pathways are Regulation of pyruvate metabolism and ESR-mediated signaling.
Activation of the essential kinase PDK1 by phosphoinositide …
Apr 6, 2022 · We propose a model of lipid-dependent PDK1 activation in which PH domain-mediated autoinhibition is relieved by PIP 3 or PI (3,4)P 2 binding, leading to strongly cooperative kinase domain...
Pyruvate dehydrogenase kinase 1 protects against neuronal injury …
Nov 7, 2023 · Research showed that Aβ-resistant nerve cells displayed increased PDK1 expression, enhanced lactate dehydrogenase A (LDHA) activity and reduced mitochondrial ROS, suggesting the potential...
3-Phosphoinositide-Dependent protein Kinase-1 (PDK1) …
The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-y lamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) Eur J Med Chem. 2010;45(4):1379–1386. doi: 10.1016/j.ejmech.2009.12.036.
Pyruvate dehydrogenase kinases (PDKs): an overview toward ... - PubMed
Apr 30, 2021 · This review seeks to elucidate the regulation of PDK activity in different species, mainly mammals, and the role of PDK inhibitors in preventing increased blood glucose, reducing injury caused by myocardial ischemia, and inducing apoptosis of tumor cells.
PDK Pirates
The PDK Pirates website is a place to share information about the Porsche PDK transmission from years of troubleshooting and repairing the transmission, assisting others in doing so and in developing the premier aftermarket solution for the Distance and Speed sensor issue.
Essential role of PDK1 in regulating cell size and development in …
We provide genetic evidence that PDK1 is essential for mouse embryonic development, and regulates cell size independently of cell number or proliferation, as well as insulin’s ability to activate PKB, S6K and RSK. Keywords: cell growth/cell size/embryonic development/PDK1/PKB–Akt/PI 3-kinase.
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