Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation.

Jan 4, 2025 · Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.

Apr 1, 2024 · ProdataKey (PDK) and DMP X1 are two important contenders in cloud-based access, each bringing a unique set of features and functionalities to the table. This article will explore their differences, delivering insight to guide businesses in selecting their ideal solution.

Dec 25, 2024 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease. Among its related pathways are Regulation of pyruvate metabolism and ESR-mediated signaling.

Apr 6, 2022 · We propose a model of lipid-dependent PDK1 activation in which PH domain-mediated autoinhibition is relieved by PIP 3 or PI (3,4)P 2 binding, leading to strongly cooperative kinase domain...

Nov 7, 2023 · Research showed that Aβ-resistant nerve cells displayed increased PDK1 expression, enhanced lactate dehydrogenase A (LDHA) activity and reduced mitochondrial ROS, suggesting the potential...

The identification of 8,9-dimethoxy-5-(2-aminoalkoxy-pyridin-3-yl)-benzo[c][2,7]naphthyridin-4-y lamines as potent inhibitors of 3-phosphoinositide-dependent kinase-1 (PDK-1) Eur J Med Chem. 2010;45(4):1379–1386. doi: 10.1016/j.ejmech.2009.12.036.

Apr 30, 2021 · This review seeks to elucidate the regulation of PDK activity in different species, mainly mammals, and the role of PDK inhibitors in preventing increased blood glucose, reducing injury caused by myocardial ischemia, and inducing apoptosis of tumor cells.

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We provide genetic evidence that PDK1 is essential for mouse embryonic development, and regulates cell size independently of cell number or proliferation, as well as insulin’s ability to activate PKB, S6K and RSK. Keywords: cell growth/cell size/embryonic development/PDK1/PKB–Akt/PI 3-kinase.