
PDK1 Gene - GeneCards | PDK1 Protein | PDK1 Antibody
Dec 25, 2024 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease. Among its related pathways are Regulation of pyruvate metabolism and ESR-mediated signaling.
Pyruvate dehydrogenase kinase - Wikipedia
Pyruvate dehydrogenase kinase (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.
Pyruvate dehydrogenase kinases (PDKs): an overview toward …
This review seeks to elucidate the regulation of PDK activity in different species, mainly mammals, and the role of PDK inhibitors in preventing increased blood glucose, reducing injury caused by myocardial ischemia, and inducing apoptosis of tumor cells.
Pan-cancer analysis reveals PDK family as potential indicators …
Mar 7, 2024 · Our study uncovers pronounced genetic heterogeneity among PDK family members, coupled with discernible clinical characteristic. Significantly, the study establishes the potential utility of PDK...
Three members of the human pyruvate dehydrogenase kinase gene …
Sep 14, 2007 · Here, we show that they are direct regulators of the family of pyruvate dehydrogenase kinase (PDK) genes, whose products act as metabolic homeostats in sensing hunger and satiety levels in key metabolic tissues by modulating the activity of the pyruvate dehydrogenase complex.
PDK1 pyruvate dehydrogenase kinase 1 [Homo sapiens (human)] - Gene …
Jan 4, 2025 · Note: PDK1 (Gene ID: 5163) and PDPK1 (Gene ID: 5170) share the PDK1 symbol/alias in common. PDK1 is a widely used alternative name for 3-phosphoinositide dependent protein kinase 1 (PDPK1). [01 Jun 2018]
PDK2 Gene - GeneCards | PDK2 Protein | PDK2 Antibody
Dec 25, 2024 · PDK2 (Pyruvate Dehydrogenase Kinase 2) is a Protein Coding gene. Diseases associated with PDK2 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Mitochondrial Disease. Among its related pathways are Regulation of pyruvate metabolism and ESR-mediated signaling.
5163 - Gene ResultPDK1 pyruvate dehydrogenase kinase 1
Gene ID: 5163, updated on 8-Feb-2025. Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals.
The expression pattern of pyruvate dehydrogenase kinases …
May 5, 2023 · The pyruvate dehydrogenase kinases (PDK; four genes: PDK1-4) are major regulatory subunits of the PDH complex, since phosphorylation of E1 catalytic subunit by PDK inhibits PDH activity 26.
Pyruvate dehydrogenase kinases (PDKs): an overview toward ... - PubMed
Apr 30, 2021 · Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it further links glycolysis with the tricarboxylic acid cycle and ATP generation.