
Platelet-derived growth factor receptor A - Wikipedia
Platelet-derived growth factor receptor A, also termed CD140a, is a receptor located on the surface of a wide range of cell types. The protein is encoded in the human by the PDGFRA gene.
PDGFRA Gene - GeneCards | PGFRA Protein | PGFRA Antibody
Dec 25, 2024 · PDGFRA (Platelet Derived Growth Factor Receptor Alpha) is a Protein Coding gene. Diseases associated with PDGFRA include Gist-Plus Syndrome and Gastrointestinal Stromal Tumor. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.
PDGFRA gene - MedlinePlus
The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Learn about this gene and related health conditions.
PDGFRA platelet derived growth factor receptor alpha [ (human)]
PDGFRA/Pdgfra gene is regulated by at least seven first exons in human and mouse. our findings support a pathogenetic relationship between telocyte hyperplasia and both inflammatory fibroid polyp and PDGFRA-mutant gastrointestinal stromal tumour (GIST).
An overview of agents and treatments for PDGFRA-mutated ...
Platelet-derived growth factor receptor A (PDGFRA) mutations occur in approximately 10–15% of gastrointestinal stromal tumors (GISTs). These tumors with PDGFRA mutations have a different pathogenesis, clinical characteristics, and treatment response ...
Role of PDGFRA - Nature
Dec 2, 2023 · Our high-resolution imaging, transcriptional profiling, and organoid assays identify regional subpopulations and supportive capacities of purified mouse corpus and antral PDGFRA + cells.
Platelet-derived growth factors and their receptors in normal …
Platelet-derived growth factors (PDGF) bind to two closely related receptor tyrosine kinases, PDGF receptor α and β, which are encoded by the PDGFRA and PDGFRB genes.
PDGFRα plays a crucial role in connective tissue remodeling - Nature
Dec 7, 2015 · Platelet derived growth factor (PDGF) plays a pivotal role in the remodeling of connective tissues. Emerging data indicate the distinctive role of PDGF receptor-α (PDGFRα) in this process.
PDGF receptor mutations in human diseases - PMC
PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in gastrointestinal stromal tumors (GISTs), inflammatory fibroid polyps and gliomas, and PDGFRB mutations drive myofibroma development. In addition, chromosomal rearrangement of ...
PDGFRA protein expression summary - The Human Protein Atlas
PDGFRA is a prognostic marker in Head and neck squamous cell carcinoma, Pancreatic adenocarcinoma
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