Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. [5][6] It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. [7] .

p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1,2). p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs (1).

Recent studies have suggested that plasma p70S6K is a reliable index for the monitoring of patient response to mTOR inhibitors. Therefore, a better understanding of p70S6K and its role in various pathological conditions could enable the development of strategies to aid diagnosis, prognosis and treatment schedules.

Jun 1, 2022 · p70 S6 kinase (p70 S6K) is best known for its regulatory roles in protein synthesis and cell growth by phosphorylating its primary substrate, ribosomal protein S6, upon mitogen stimulation.

Feb 12, 2022 · We demonstrate that p70 ribosomal S6 kinase activity peaks in oligodendrocyte lineage cells at the time when they transition to myelinating oligodendrocytes during developmental myelination in the mouse spinal cord.

p70 S6 kinase is a mitogen activated Ser/Thr protein kinase that is required for cell growth and G1 cell cycle progression (1,2). p70 S6 kinase phosphorylates the S6 protein of the 40S ribosomal subunit and is involved in translational control of 5' oligopyrimidine tract mRNAs (1).

P70S6 Kinase, also known as S6K1, is a serine/threonine kinase that plays a crucial role in controlling translation by phosphorylating key proteins involved in protein synthesis. It is a downstream effector of mTORC1 and ERK signaling pathways, influencing synaptic plasticity and cell proliferation in the context of neuroscience.

Feb 12, 2022 · We demonstrate that p70 ribosomal S6 kinase activity peaks in oligodendrocyte lineage cells at the time when they transition to myelinating oligodendrocytes during developmental myelination in the mouse spinal cord.

Apr 4, 2002 · We report here for the first time that the specific MAPK kinase (MEK) inhibitor, PD-98059, not only completely knocked out granulocyte-macrophage colony-stimulating factor (GM-CSF)- stimulated MAPK activity, but it also partially (~70%) inactivated the …

Both S6K1 and S6K2 have two isoforms, known as S6K1S and S6K1L, and S6K2S and S6K2L. S6K1 is the isoform that has been studied most intensely and whose function is best understood, especially in the nervous system. Similar to many proteins, S6K1 contains multiple phosphorylation sites.