P70-S6 Kinase 1 - Wikipedia
Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. …
p70 S6 kinase as a therapeutic target in cancers: More than
Jun 1, 2022 · p70 S6 kinase (p70 S6K) is best known for its regulatory roles in protein synthesis and cell growth by phosphorylating its primary substrate, ribosomal protein S6, upon mitogen …
The mTOR-S6 kinase pathway promotes stress granule assembly
Mar 9, 2018 · Here we show that the mTOR effector kinases S6 kinase 1 (S6K1) and S6 kinase 2 (S6K2) localise to stress granules in human cells and are required for their assembly and …
p70 S6 kinase and actin dynamics - PubMed Central (PMC)
p70 S6 kinase (p70S6K), a member of the AGC serine/threonine kinase family, was initially identified as a key player, together with its downstream effector S6, in the regulation of cellular …
p70 Ribosomal protein S6 kinase (Rps6kb1): an update - PubMed
The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of …
Up-Regulation of Phosphorylated/Activated p70 S6 Kinase and Its ...
The ribosomal S6 protein kinase p70 S6 kinase is known for its role in modulating cell-cycle progression, cell size, and cell survival. In response to mitogen stimulation, p70 S6 kinase …
p70S6 kinase regulates oligodendrocyte differentiation and is …
Feb 12, 2022 · We demonstrate that p70 ribosomal S6 kinase activity peaks in oligodendrocyte lineage cells at the time when they transition to myelinating oligodendrocytes during …
p70 Ribosomal protein S6 kinase - Journal of Clinical Pathology
The Rps6kb1 gene encodes the 70 kDa ribosomal protein S6 kinase (p70S6K), which is a serine/threonine kinase regulated by phosphoinositide 3-kinase (PI3K)/mammalian target of …
Regulation of the p70 S6 Kinase by Phosphorylation in Vivo
We employed phospho-specific anti-peptide antibodies to examine the relative phosphorylation at several of these sites in wild type and various p70 mutants, in serum-deprived cells, and in …
Inhibition of mTOR complex 1/p70 S6 kinase signaling elevates
Jul 17, 2019 · We demonstrate that disruption of this signaling pathway with mTOR inhibitors, raptor knockdown or p70S6K inhibitors elevated PD-L1 levels in some lung and other cancer …