
Application of p16/Ki-67 dual-staining cytology in cervical cancers
p16/Ki-67 dual-staining cytology is of great significance in screening and triaging of cervical cancer and precancerous lesions. It provides a good risk marker for the stratification of HPV …
For HPV-Positive Women, Test Can Guide Screening Follow-Up
Oct 11, 2018 · It measures the presence of two specific proteins, p16 and Ki-67, in a sample of cervical cells. The expression of p16 is strongly linked with HPV infection, and Ki-67 is used as …
Efficacy of p16 and Ki-67 immunostaining in the detection of …
p16 and Ki-67 immunohistochemistry can be used as an ancillary method for the diagnosis of squamous intraepithelial lesion (SIL) versus atrophic change and atypical squamous metaplasia.
p16/Ki-67 Dual Stain (DS) is a cytology-based test for detection of cervical precancer that has been approved by the FDA for triage of positive test results in HPV screening and HPV …
Comparison of Ki67 index and P16 expression in different grades …
Assessment of P16 expression and Ki67 index can be used to distinguish low grade (CIN1) intraepithelial lesion from high grade (CIN2/3) intraepithelial or precancerous lesions. Key …
The value of Ki67 for the diagnosis of LSIL and the problems of p16 …
May 9, 2022 · The results indicated that Ki67 had high specificity and sensitivity in distinguishing LSIL from normal cervix. p16 was diffusely and strongly positive in some LSILs, and some …
Five-Year Risk of Cervical Precancer Following p16/Ki-67 Dual …
Triage with p16/Ki-67 dual-stain (DS) testing has shown high sensitivity and specificity for detection of cervical precancers; however, longitudinal studies are needed to determine the …
Application of p16/Ki-67 dual-staining cytology in cervical cancers
Jun 2, 2019 · There is increasing evidence that p16/Ki-67 dual-staining cytology can be used as an alternative biomarker, showing overall high sensitivity and specificity for identifying high …
Journal of Lower Genital Tract Disease - LWW
Dual staining of cytology specimens detects a marker of HPV-related oncogene activity (p16, a tumor suppressor protein) and a marker of cell proliferation (Ki-67) that, when detected …
Performance of p16/Ki-67 Immunostaining to Detect Cervical …
Jul 30, 2012 · We show that p16/Ki-67 does best at detecting precancers with the highest risk of progression to cancer, namely, those related to HPV16 among women 30 years and older. …