p16/Ki-67 dual-staining cytology is of great significance in screening and triaging of cervical cancer and precancerous lesions. It provides a good risk marker for the stratification of HPV …

Oct 11, 2018 · It measures the presence of two specific proteins, p16 and Ki-67, in a sample of cervical cells. The expression of p16 is strongly linked with HPV infection, and Ki-67 is used as …

p16 and Ki-67 immunohistochemistry can be used as an ancillary method for the diagnosis of squamous intraepithelial lesion (SIL) versus atrophic change and atypical squamous metaplasia.

p16/Ki-67 Dual Stain (DS) is a cytology-based test for detection of cervical precancer that has been approved by the FDA for triage of positive test results in HPV screening and HPV …

Assessment of P16 expression and Ki67 index can be used to distinguish low grade (CIN1) intraepithelial lesion from high grade (CIN2/3) intraepithelial or precancerous lesions. Key …

May 9, 2022 · The results indicated that Ki67 had high specificity and sensitivity in distinguishing LSIL from normal cervix. p16 was diffusely and strongly positive in some LSILs, and some …

Triage with p16/Ki-67 dual-stain (DS) testing has shown high sensitivity and specificity for detection of cervical precancers; however, longitudinal studies are needed to determine the …

Jun 2, 2019 · There is increasing evidence that p16/Ki-67 dual-staining cytology can be used as an alternative biomarker, showing overall high sensitivity and specificity for identifying high …

Dual staining of cytology specimens detects a marker of HPV-related oncogene activity (p16, a tumor suppressor protein) and a marker of cell proliferation (Ki-67) that, when detected …

Jul 30, 2012 · We show that p16/Ki-67 does best at detecting precancers with the highest risk of progression to cancer, namely, those related to HPV16 among women 30 years and older. …