Jun 10, 2024 · We discovered that the multicopy homeobox gene, oocyte-specific homeobox 4 (Obox4), promotes Dux -less ZGA. Obox4 is abundantly expressed in mouse 2C-embryos, 2C-like mESCs, and totipotent blastomere-like cells (TBLCs) (Shen et al., 2021).

Jul 17, 2023 · Here we show that OBOX, a PRD-like homeobox domain transcription factor family (OBOX1–OBOX8) 3, 4, 5, are key regulators of mouse ZGA. Mice deficient for maternally transcribed Obox1 / 2 / 5 /...

We discovered that the multicopy homeobox gene, oocyte-specific homeobox 4 (Obox4), promotes Dux -less ZGA. Obox4 is abundantly expressed in mouse 2C-embryos, 2C-like mESCs, and totipotent blastomere-like cells (TBLCs) (Shen et al., 2021).

Here, we showed that OBOX, a PRD-like homeobox domain TF family (OBOX1–8) 3 – 5, are key regulators of mouse ZGA. Mice deficient for maternally transcribed Obox1/2/5/7 and zygotically expressed Obox3/4 had a 2–4 cell arrest accompanied by impaired ZGA.

Oocyte-specific homeobox 4 (Obox4) is preferentially expressed in oocytes and plays an important role in the completion of meiosis of oocytes. However, the Obox4 expression pattern has not been reported yet. In this study, we investigated the ...

Feb 5, 2010 · Obox genes are preferentially expressed in the ovary, testis and oocyte, and play important roles in many developmental processes. In this study, we report that Obox4 and Obox6 are expressed in mouse embryonic stem cells (mESCs) and that Obox4 regulates histone family gene expression in mESCs.

Jul 5, 2022 · Genome-wide epigenetic profiling revealed that OBOX4 binds to MERVL LTRs as well as murine endogenous retroviruses with lysine tRNA primer (MERVK) LTRs, and mediates the deposition of active histone modifications. Our study identified OBOX4 as a pioneer factor that provides genetic redundancy to pre-implantation development.

Jan 4, 2024 · It is identified that the multicopy homeobox gene, Obox4, encodes a transcription factor that is highly expressed in mouse 2-cell embryos and redundantly drives ZGA, a transcription factor that provides genetic redundancy to pre-implantation development.

Jul 4, 2022 · Genome-wide epigenetic profiling revealed that OBOX4 binds to MERVL LTRs as well as murine endogenous retroviruses with lysine tRNA primer (MERVK) LTRs, and mediates the deposition of active...

Oct 30, 2022 · In the present study, we present multiple lines of evidence that the multicopy mouse homeobox gene, Obox4, encodes a transcription factor that is highly expressed in mouse 2-cell embryos and redundantly drives ZGA.

Apr 23, 2024 · Obox family genes constitute a large cluster on the mouse chromosome 7. Obox3 and Obox4 are highly duplicated in this cluster, while other Obox family genes (Obox1, Obox2, Obox5, Obox6, Obox7, and Obox8) are present as a single-copy genes.

Jun 10, 2024 · Obox family members with redundant functions are expressed in high dose at peri-ZGA stages to ensure rapid ZGA. Obox4 evolved as a divergent Obox family member that provides functional redundancy to Dux.

Mar 31, 2013 · Oocyte-specific homeobox 4 ( Obox4) is preferentially expressed in oocytes and plays an important role in the completion of meiosis of oocytes. However, the Obox4 expression pattern has not been reported yet. In this study, we investigated the subcellular localization of Obox4 using a green fluorescent protein (GFP) fusion expression system.

Previously, we showed that oocyte-specific homeobox 4 (Obox4) is critical for maintaining the intact nuclear membrane of the germinal vesicle (GV) in oocytes and for completing meiosis at the metaphase I–II (MI–MII) transition.

Obox4 stands out in this context, because Ji and colleagues found that restoring its expression could not compensate for loss of the other genes. This suggests that the OBOX4 protein might have...

Objective: Previously, we found that oocyte specific homeobox (Obox) 4 plays significant role in completion of meiosis specifically at meiosis I-meiosis II (MI-MII) transition. The purpose of this study was to determine the mechanism of action of Obox4 in oocyte maturation by evaluating downstream signal networking.

Jan 1, 2007 · Oocyte-specific homeobox 4 (Obox4) is preferentially expressed in oocytes and plays an important role in the completion of meiosis of oocytes.

Jan 14, 2016 · Oocyte-specific homeobox 4 (Obox4) is an upstream negative regulator of MPF/MAPK3/1 as well as STAT3 activation during meiotic resumption from diplotene arrest. Obox4 inhibits meiotic...

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