High-throughput interrogation of programmed ribosomal ... - Nature
Jun 16, 2020 · Programmed ribosomal frameshifting (PRF) is the controlled slippage of the translating ribosome to an alternative frame. This process is widely employed by human …
The Deficiency of Hypusinated eIF5A Decreases the …
Feb 1, 2024 · Titration of OAZ via AZIN prevents OAZ from targeting ODC for degradation, stabilizing ODC, and enhancing putrescine synthesis, promoting further +1 PRF. Moreover, …
Translation Elongation and Recoding in Eukaryotes - PMC
OAZ downregulates polyamine synthesis by stimulating ubiquitin-independent degradation of ornithine decarboxylase (ODC), the enzyme that catalyzes the first step in polyamine …
Translational recoding signals: Expanding the synthetic biology …
May 10, 2019 · Ornithine decarboxylase (ODC), a key enzyme in this process, is degraded by ornithine decarboxylase antizyme (OAZ). Synthesis of OAZ requires a +1 PRF event that is …
Programmed −1 ribosomal frameshifting (−1 PRF) has been identified as a mechanism to regulate the expression of many viral genes and some cellular genes. The slippery site of −1 PRF has …
Evolution of +1 Programmed Frameshifting Signals and Frameshift ...
Jul 12, 2006 · A similar shifty stop +1 frameshift in the ornithine decarboxylase antizyme (OAZ) of eukaryotes provides a method of feedback regulation in response to downstream metabolic …
Phenotypic mutations contribute to protein diversity and shape …
A well‐studied example of eukaryotic frameshifting is the ornithine decarboxylase antizyme (OAZ). 55, 103 The antizyme, which is needed to degrade polyamines, requires a +1 frameshift to be …
High frequency of +1 programmed ribosomal frameshifting in
Feb 19, 2016 · Programmed −1 ribosomal frameshifting (−1 PRF) has been identified as a mechanism to regulate the expression of many viral genes and some cellular genes. The …
Roles of polyamines in translation - PMC
Schematic representation of polyamine control of OAZ, AZIN, and AdoMetDC mRNA translation. A, OAZ is encoded by two partially overlapping ORFs linked through ribosomal +1 frameshifting.
Nov 14, 2018 · Programmed ribosomal frameshifting (PRF), i.e. controlled slippage of the ribosome, is a mechanism by which two proteins with alternative C termini can be generated …
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