Presence or absence of an anion gap (AG) can help to distinguish the underlying etiology. In general, with a pure or uncompensated metabolic acidosis, every 10 mEq/L fall in bicarbonate (HCO 3) results in an average pH fall of 0.15. Neonates have an average arterial pH of 7.37 (range of 7.35–7.45).

Dec 28, 2016 · Presence or absence of an anion gap (AG) can help to distinguish the underlying etiology. In general, with a pure or uncompensated metabolic acidosis, every 10 mEq/L fall in bicarbonate (HCO 3) results in an average pH fall of 0.15. Neonates have an average arterial pH of 7.37 (range of 7.35–7.45).

Sep 14, 2023 · Metabolic acidosis is a biochemical abnormality defined by an increase in blood hydrogen ion (H +) concentration or a reduction in serum bicarbonate (HCO 3) concentration. It is either an acute or chronic process and is secondary to a wide range of underlying disorders.

Blood gases are helpful to assess the effectiveness of ventilation, circulation and perfusion. Blood gases can be performed from cord, arterial, venous or capillary specimens. Repeated arterial stabs are strongly discouraged, as they are painful and do …

In neonates, classic scenarios in which a metabolic disor-der is more likely include those in which a neonate has severe metabolic acidosis with an anion gap, lactic acidosis, or hyperammonemia, which can also occur together.

Neonatal metabolic acidosis (NMA) is the accumulation of non-carbonic acid equivalents, which arises from excessive production or inadequate excretion of hydrogen ions or from an increased loss of bicarbonate (1). Neonatal metabolic acidosis is associated with poor clinical outcomes (2).

Objectives: To determine in critically ill newborn infants (1) the range of the serum anion gap without metabolic acidosis and (2) whether the serum anion gap can be used to distinguish newborns with lactic acidosis from those with hyperchloremic metabolic acidosis.

Objectives: To determine in critically ill newborn infants (1) the range of the serum anion gap without metabolic acidosis and (2) whether the serum anion gap can be used to distinguish newborns with lactic acidosis from those with hyperchloremic metabolic acidosis.

The occurrence of acidosis in a newborn baby should initiate several actions, aimed simultaneously at treatment and diagnosis. An initial blood gas determination, accompanied by the results of serum electrolytes and glucose, will, in most instances, separate respiratory from metabolic causes.

Serum anion gap (SAG) = serum Sodium – (serum Bicarbonate+ serum chloride) The normal values vary from 8 to 16 mmol/l. It represents the difference between measured cation and measured anion. Calculating AG is important step in approaching the differential diagnosis of metabolic acidosis.