Dec 25, 2024 · NTRK1 (Neurotrophic Receptor Tyrosine Kinase 1) is a Protein Coding gene. Diseases associated with NTRK1 include Insensitivity To Pain, Congenital, With Anhidrosis and Thyroid Carcinoma, Familial Medullary. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.

Tropomyosin receptor kinase A (TrkA), [5] also known as high affinity nerve growth factor receptor, neurotrophic tyrosine kinase receptor type 1, or TRK1-transforming tyrosine kinase protein is a protein that in humans is encoded by the NTRK1 gene.

The NTRK1 gene provides instructions for making a protein that is essential for the development and survival of nerve cells (neurons), especially those that transmit information about sensations such as pain, temperature, and touch (sensory neurons).

Gene ID: 4914, updated on 19-Feb-2025. This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.

NTRK gene fusions involving either NTRK1, NTRK2, or NTRK3 (encoding the neurotrophin receptors TRKA, TRKB, and TRKC, respectively) are oncogenic drivers of various adult and paediatric tumour types. These fusions can be detected in the clinic using ...

Oct 6, 2024 · Clinical resource with information about NTRK1, Hereditary insensitivity to pain with anhidrosis, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

Sep 16, 2021 · NTRK1–3 fusions have now been identified in a number of different tumor types, including sarcomas, carcinomas, and hematologic malignancies in adults and children. The discovery of NTRK...

Feb 8, 2025 · Title: A recurrent NTRK1 tyrosine kinase domain mutation pair is characteristic in a subset of dedifferentiated liposarcomas. TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression.

The NTRK1 gene encodes the neurotrophic tyrosine kinase-1 receptor and belongs to a family of nerve growth factor receptors whose ligands include neurotrophins. Neurotrophins and their receptors play an important role in regulating development of both the central and the peripheral nervous systems.

Neurotrophic tropomyosin receptor kinase (NTRK) gene rearrangements have recently emerged as targets for cancer therapy, because novel compounds have been developed that are selective inhibitors of the constitutively active fusion proteins that arise from these molecular alterations.