• Our work shows that WTX-124, a pro-drug containing wild-type IL-2, is selectively processed and activated in tumors and is efficacious in murine models, even in the presence of regulatory T cells • WTX-124 activity is dependent on the processing of the pro-drug as a non-cleavable version of WTX-124 (WTX-124-NC) is not efficacious in our ...

In this study, we discovered that loss of WTX could activate CDC42 through disrupting the interaction between CDC42 and its inhibitor Rho GDP-dissociation inhibitors (RhoGDIa), which promotes...

WTX-330 is being developed for the treatment of relapsed or refractory, advanced or metastatic solid tumors, or lymphomas, and is currently in clinical development (NCT05678998).

WTX 124 is an inducible IL-2 prodrug that is selectively activated in the tumor microenvironment. Administration of WTX-124 generates potent antitumor immunity by activating tumor-infiltrating lymphocytes while preventing the toxicity associated with systemic, high dose IL-2 treatment.

WTX-330, a conditionally activated IL-12 INDUKINETM therapy, releases IL-12 selectively in the tumor microenvironment to activate anti-tumor immune responses and induce regressions in mouse tumor models

• WTX-124 is a tumor selective inducible IL-2 prodrug that generates significant anti-tumor activity in a CD8+ T Cell dependent manner • WTX -124 has a better therapeutic window than rhIL 2 or half life

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WTX-124 is designed to include maintenance of full IL-2 potency, high affinity blockade of IL2 - IL2Rβ/IL2Rγ interaction in systemic circulation and non-tumor tissues, half-life extension for optimal tumor exposure and proprietary tumor-selective protease activation.

A first-in-human, Phase 1, open-label, multicenter study of WTX-330 administered as a monotherapy to patients with advanced or metastatic solid tumors or non-Hodgkin lymphoma.

pro-drug as a non-cleavable version of WTX-124 (WTX-124-NC) is not efficacious in our models • Mechanistically, WTX-124 induces intratumoral activation of NK cells and CD8+ T cells as well as a proinflammatory phenotype in Tregs, and generates long-term memory in treated animals • WTX-124 possesses good PK characteristics in mouse

WTX-124 exhibits approximately dose-proportional PK with very low levels of active IL-2 (<1% of prodrug). Tumor biopsies are being analyzed for changes in the frequency and functionality of tumor-infiltrating lymphocytes, PD-L1 expression, and immune cell gene expression.

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Mar 21, 2022 · WTX (Wilms Tumor gene on X chromosome) is an X-linked tumor suppressor discovered in the Wilms tumor [9-11]. WTX forms a complex with β-TrCP2, β-catenin, APC, and AXIN1 to promote the ubiquitination of β-catenin protein, which inhibits the activation of WNT signaling pathway in Wilms tumors [12-14].

• WTX-330 is designed to be a first-in-class, systemically delivered, conditionally activated IL-12 INDUKINE™ molecule for the treatment of relapsed or refractory advanced or metastatic solid tumors or lymphoma • Since human IL-12 is not active in mouse cells, an INDUKINE surrogate containing a chimeric IL-12 molecule was designed (mWTX-330)

FAM123B/WTX/AMER1 (hereafter referred to as WTX) is located on the X chromosome and encodes a tumor suppressor protein that is lost or mutated in up to 30% of the cases of Wilms tumor, the most common pediatric kidney cancer (1–3).

Jul 5, 2023 · WTX-330 is being developed for the treatment of relapsed or refractory, advanced or metastatic solid tumors, or lymphomas, and is currently in clinical development (NCT05678998).

Jan 27, 2024 · Check out the most recent NAM3km simulated radar and snowfall projection. Tune in on Facebook and Youtube for a live update on the upcoming weather pattern at 4:30. I see 3 chances for snowfall over the next 10 days around WNC so buckle up, this warm weather is gone.

Key features of WTX-330 include peripheral blockade (green) of the IL-12–IL-12 receptor interaction to limit systemic toxicity, half-life extension (blue) for optimal exposure in tumors and conditional activation in the tumor microenvironment.

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WTX-330 is an IL-12 INDUKINETM molecule that uses a prodrug strategy to leverage the favorable proinflammatory activities of this potent and pleiotropic cytokine to safely stimulate antitumor immune responses Enrollment in the dose escalation part of the WTX-330x2101 first-in-human study is presently ongoing Creating Powerful Proinflammatory