May 18, 2022 · Here, we report that both FSP1-CoQ 10 -NADH and GSH-GPx-4 pathways inhibit retinal ferroptosis in sodium iodate (SIO)-induced retinal degeneration pathologies in human primary RPE cells...

GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation. GPX4 was first discovered in biochemistry laboratories of the University of Padua, where it was described as an enzyme capable of protecting against peroxidation.

Jan 25, 2025 · This study showed that Gin B improved cerebral I/R-induced ferroptotic cell death by activating the GPX4-GSH and FSP1-CoQ10-NADH pathways, providing a new mechanism of Gin B for cerebral I/R treatment.

Jan 1, 2022 · Nicotinamide mononucleotide (NMN) which is a direct and potent NAD + precursor supplement, rescued the imbalanced NAD + /NADH ratio, recruited the production of GSH and promoted resistance to lipid peroxidation in a GPX4-dependent manner.

Oct 30, 2022 · Loss of GPX4 protein expression in NRF1-deficient cells sensitized cells to ferroptosis, whereas in cells lacking GPX4, overexpression of NRF1 failed to inhibit ferroptosis.

Oct 21, 2019 · NCI-H460 GPX4 KO lines and FSP1 KO GPX4 KO lines were generated by infection with lentiCRISPR v2-Hygro (Addgene plasmid no. 98291) virus, selection in medium containing 250 μg/ml...

Dec 15, 2024 · NMN recruits GSH, rebalances NAD + /NADH, enhances GPX4 expression and reduces ferroptosis, leading to decreased TNFα and IL-8 expression. Consequently, hippocampal neuroinflammation levels are downregulated.

May 1, 2022 · Here, we report that both FSP1-CoQ10-NADH and GSH-GPx-4 pathways inhibit retinal ferroptosis in sodium iodate (SIO)-induced retinal degeneration pathologies in human primary RPE cells...

Here, we report that both FSP1-CoQ 10 -NADH and GSH-GPx-4 pathways inhibit retinal ferroptosis in sodium iodate (SIO)-induced retinal degeneration pathologies in human primary RPE cells (HRPEpiC), ARPE-19 cell line, and mice.

May 18, 2022 · Here, we report that both FSP1-CoQ 10 -NADH and GSH-GPx-4 pathways inhibit retinal ferroptosis in sodium iodate (SIO)-induced retinal degeneration pathologies in human primary RPE cells (HRPEpiC), ARPE-19 cell line, and mice.