Nov 18, 2022 · Emerging evidence suggests that mutp53 is highly associated with advanced malignancies and poor prognosis, which makes it a target for development of novel cancer therapies. Herein, we...

Mar 31, 2022 · Mutation of the TP53 tumor suppressor gene is the most common genetic alteration in cancer, and almost 1000 alleles have been identified in human tumors.

May 9, 2024 · Here, we review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that contribute to tumor suppression.

Apr 12, 2021 · Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function activities. We report a mechanism by which mtp53 suppresses both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance.

Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer various gain-of-function (GOF) activities that impacts molecules and pathways now regarded as central for tumor development and progression.

Dec 11, 2018 · Mutant p53 orchestrates stress response mechanisms that facilitate tumor cell survival and adaptation to multiple intrinsic and extrinsic stress conditions (genotoxic, oxidative, and...

Jun 2, 2017 · Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently mutated gene in human cancer, and over half of human cancers contain p53 mutations. Majority of p53 mutations in cancer are missense mutations, leading to the expression of full-length mutant p53 (mutp53) prot …

Apr 12, 2021 · Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function activities. We report a mechanism by which mtp53 suppresses both cell-autonomous and non-cell-autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance.

6 days ago · Pancreatic cancer (PC) is a highly metastatic malignancy. More than 80% of patients with PC present with advanced-stage disease, preventing potentially curative surgery. The neuropeptide Y (NPY) system, best known for its role in controlling energy homeostasis, has also been shown to promote tumorig …

Jul 2, 2024 · There was a substantially impact of mutant p53 over-expression on lymphoma development in an Eμ-Myc model carrying p53 +\+ tumors. A molecular analysis unveiled insights into the dominant-negative mechanisms of p53 mutants: mutant p53 does not uniformly suppress wild-type function.