In addition, amino acid consumption will stimulate mTORC1 through the branched chain amino acid/Rag pathway. Thus dietary restriction inhibits mTORC1 signaling through both upstream pathways of mTORC that converge on the lysosome. [55]

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Developmental cell. 2006;11:859–871. doi: 10.1016/j.devcel.2006.10.007.

The functions of the components of the mTORC complexes have been studied using knockdowns and knockouts and were found to produce the following phenotypes: NIP7 : Knockdown reduced mTORC2 activity that is indicated by decreased phosphorylation of mTORC2 substrates.

mTOR [mechanistic target of rapamycin] is a serine/threonine protein kinase that, as part of mTORC1 (mTOR complex 1), acts as an important molecular connection between nutrient signals and the metabolic processes indispensable for cell growth. While there has been pronounced interest in the upstream …

Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell. 2006;11:859–871. doi: 10.1016/j.devcel.2006.10.007.

Jan 2, 2019 · In this Review, we introduce the landmark discoveries in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations of key components of the mTORC signalling ...

Oct 2, 2023 · The mammalian target of rapamycin (mTOR) is a protein kinase that controls cellular metabolism, catabolism, immune responses, autophagy, survival, proliferation, and migration, to maintain ...

Nov 21, 2024 · The activation of mTORC1 is intricately linked to its subcellular localization, with the Rag GTPases controlling its lysosomal recruitment in response to nutrient cues. Acharya and Demetriades uncover another layer of regulation of mTORC1 localization, wherein its intrinsic kinase activity governs its own lysosomal tethering by influencing RagA nucleotide loading.

Aug 23, 2023 · The Ser/Thr kinase mechanistic target of rapamycin (mTOR) is a central regulator of cellular metabolism. As part of mTOR complex 1 (mTORC1), mTOR integrates signals such as the levels of nutrients ...

Localization of mTORCs and association with specific regulators and metabolic enzymes in cellular compartments may serve to not only modulate mTORC activity but also recruit other signaling and metabolic effectors and thus trigger a cascade of events that ultimately induce gene expression of metabolic effectors.