Jul 6, 2016 · Myeloid-derived suppressor cells (MDSCs) have emerged as major regulators of immune responses in cancer and other pathological conditions. In recent years, ample...

Predominantly, human M-MDSCs have been described as CD11b + CD14 + CD33 + HLA-DR low/neg, and G-MDSCs as CD11b + CD15 + HLA-DR low CD66b +. Their mouse counterparts …

Apr 6, 2017 · Using co-culture experiments and mouse transcriptome analyses in syngeneic mouse models, we provide evidence that tumour-infiltrated mMDSCs facilitate tumour cell …

Feb 1, 2021 · Myeloid-derived suppressor cells (MDSCs) are pathologically activated neutrophils and monocytes with potent immunosuppressive activity. They are implicated in the regulation …

Myeloid-derived suppressor cells (MDSCs) expand during pathological conditions in both humans and mice and their presence is linked to poor clinical outcomes for cancer patients. Studying …

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population expanded in cancer and other chronic inflammatory conditions. Here the authors identify the challenges and …

Mar 29, 2023 · Myeloid-derived suppressor cells (MDSCs) are an immature and heterogeneous cell population that can inhibit T-cell function. In the 1970s, a population of …

Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of immune cells from the myeloid lineage (a family of cells that originate from bone marrow stem cells). MDSCs expand …

Mouse monocytic MDSCs are CD11b + Ly-6C + Ly-6G -/low mononuclear cells with low side scatter (SSC), while granulocytic MDSCs are CD11b + Ly-6C - Ly-6G + polymorphonuclear …

May 11, 2021 · Here, we propose such a framework to classify MDSCs as discrete cell states based on activation signals in myeloid populations leading to suppressive modes …