In an ideal mouse system, one could quickly generate tumors resembling human tumor cells at both the genetic and morphologic levels. Accomplishing this using mouse models has provided an indispensable tool for studying tumor initiation, maintenance, progression, and …

One of the most common uses of syngeneic tumor models involves using carcinogens to induce tumor formation in mice and directly evaluating these tumor-bearing mice for antitumor efficacy of tumor immunotherapies.

Within this article, we will cover the principal mouse models used in oncology research, beginning with behavioral science of animals vs. humans, and continuing on with genetically engineered mice, microsurgical-induced cancer models, and avatar …

Jun 9, 2020 · This review discusses the current immunocompetent and immunocompromised mouse models of human tumors that are used to evaluate the effectiveness of immunotherapeutic agents, in particular chimeric antigen receptor (CAR) T-cells and immune checkpoint inhibitors.

Transgenic GEM are mutant mice that express oncogenes or dominant-negative tumour-suppressor genes (TSGs) in a non-physiological manner owing to ectopic promoter and enhancer elements....

Jan 9, 2025 · Here, we analyze neoepitope-specific CD8 cells of distinct avidities and show that low-avidity T cells are the sole mediators of cancer control in mice and are solely responsive to checkpoint...

Feb 28, 2025 · When plotting tumor progression, due to limited number of mice, S6.KPP and S7.KPP were combined as doubling time of the Control tumor volumes were similar in the 7-week period analyzed, and some ...

1 day ago · In the mouse, these cells do not give rise to tumors unless exposed to the tumor promoter TPA. Tissue damage and regenerative proliferation, but not normal cell turnover, consistently trigger tumor formation. Wounding, promoter treatment, and obesity enhance promotion without increasing mutational burden, supporting the possibility of future ...

There are hundreds of JAX® Mice strains available for cancer research and drug efficacy testing. The table below summarizes the tumor latency and other features for over 40 of the most commonly used JAX® Mice cancer models. Click cancer types for detailed descriptions of mouse models. 100006 Cancer types: bladder.

Nov 2, 2018 · Using mouse colon adenocarcinoma model MC38 implanted in young and mature mice, we show that age substantially influences the number of tumor-infiltrating cytotoxic CD8 + T cells, which control cancer progression.