Nov 19, 2022 · Depleting medin from the samples before injection prevented plaques. Together, these data suggested that medin promotes Aβ deposition. Plaque Promotion. Nine-month-old APP23 mice (left) have few amyloid plaques (blue) in the hippocampus, unless they were previously injected with seeds of aggregated medin (middle) or Aβ (right). [Courtesy of ...

Nov 19, 2022 · The authors’ data suggests that medin generated by vascular smooth-muscle cells, and possibly other cells of the neurovascular unit, could play a role in accelerating Aβ pathology and CAA, based on their immunostaining and RNA-Seq analysis. But, how medin interacts with Aβ to promote fibrilization remains still to be investigated.

Medin aggregation causes cerebrovascular dysfunction in aging wild-type mice. Proc Natl Acad Sci U S A . 2020 Sep 22;117(38):23925-23931. Epub 2020 Sep 8 PubMed .

Endothelial Immune Activation by Medin: Potential Role in Cerebrovascular Disease and Reversal by Monosialoganglioside-Containing Nanoliposomes. J Am Heart Assoc. 2020 Jan 21;9(2):e014810. Epub 2020 Jan 13 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a …

Lactadherin binds to elastin--a starting point for medin amyloid formation?. Amyloid. 2006 Jun;13(2):78-85. PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

Role of aggregated medin in the pathogenesis of thoracic aortic aneurysm and dissection. Lab Invest. 2007 Dec;87(12):1195-205. Epub 2007 Oct 1 PubMed. Recommends. Please login to recommend the paper. Comments. No Available Comments. Make a Comment. To make a comment you must login or register.

Jul 9, 2011 · When visualized, these models will distributed over a 18 month timeline demarcated at the following intervals: 1mo, 3mo, 6mo, 9mo, 12mo, 15mo, 18mo+.

May 21, 2002 · Congophillic, dense-core amyloid plaques first appear at 6 months, and increase in size and number with age. Amyloid plaques can occupy more than 25% of the neocortex and hippocampus in 24 month-old mice (Sturchler-Pierrat et al., 1997; Calhoun et al., 199

Aug 10, 2023 · Jonas Neher of the German Center for Neurodegenerative Diseases in Tübingen previously nominated medin, a protein fragment that aggregates into a vascular amyloid that promotes CAA, as a potential marker (Nov 2022 news). His group has developed highly specific antibodies against medin and is using these to test its association with CAA, Neher ...

Sep 8, 2023 · A small fragment of MFG-E8, known as medin, accumulates as an amyloid in blood vessel walls and has been linked to cerebral amyloid angiopathy (Nov 2022 news). Tastier Morsels. Cultured mouse microglia (nuclei are gray) eat many more synapses (red) from AD (right) than control brain (left).