Mdsc Heart - Search

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PubMed
https://pubmed.ncbi.nlm.nih.gov
Cardioprotective Role of Myeloid-Derived Suppressor Cells in …
Jul 10, 2018 · Our findings revealed a cardioprotective role of MDSCs in HF by their antihypertrophic effects on cardiomyocytes and anti-inflammatory effects through interleukin-10 and nitric oxide. Pharmacological targeting of MDSCs by rapamycin constitutes a promising …
- Author: Ling Zhou, Kun Miao, Bingjiao Yin, Huaping Li, Jiahui Fan, Yazhen Zhu, Hongping Ba, Zunyue Zhang, Fa...
- Publish Year: 2018
Nature
https://www.nature.com › articles
G-MDSCs promote aging-related cardiac fibrosis by activating ...
Jun 8, 2021 · Through RNA-seq and biochemical approaches, we found that granulocytic MDSCs (G-MDSCs) accumulated significantly in the aging heart compared with monocytic MDSCs (M …
- Author: Shu-Ning Sun, Shi-Hao Ni, Yue Li, Xin Liu, Jian-Ping Deng, Zi-Xin Chen, Huan Li, Wen-Jun Feng, Yu-Sh...
- Publish Year: 2021
PubMed
https://pubmed.ncbi.nlm.nih.gov
G-MDSCs promote aging-related cardiac fibrosis by activating ...
Jun 8, 2021 · Through RNA-seq and biochemical approaches, we found that granulocytic MDSCs (G-MDSCs) accumulated significantly in the aging heart compared with monocytic MDSCs (M …
- Author: Shu-Ning Sun, Shi-Hao Ni, Yue Li, Xin Liu, Jian-Ping Deng, Zi-Xin Chen, Huan Li, Wen-Jun Feng, Yu-Sh...
- Publish Year: 2021
Studies of Mdsc Heart
PubMed
G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence
Aging is one of the most prominent risk factors for heart failure. Myeloid-derived suppressor cells (MDSCs) accumulate in aged tissue and have been confirmed to be associated with various aging-related diseases. However, the role of MDSCs in the aging heart remains unknown. Through RNA-seq and bioch...
Author: Shu-Ning Sun
Published: 2021/06/08
Keywords: National In…
National Center for Biotechnology Information
Blocking the A2B adenosine receptor alleviates myocardial damage by inhibiting spleen-derived MDSC mobilisation after acute myocardial infarction
Background Myeloid-derived suppressor cell (MDSC) mobilisation is an important immune event in acute myocardial infarction (AMI). The A2B adenosine receptor (A2BAR) plays key role in regulating MDSC function, but its specific involvement in MDSC mobilisation in AMI remains unclear. Methods In...
Author: Zongying Yu, …
Published: 2022
Publication: Ann Med. …
ScienceDirect
Research Article Analysis of therapeutic potential of monocytic myeloid-derived suppressor cells in cardiac allotransplantation
Background Myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) are attractive immune cells to induce immune tolerance. To explore a strategy for improving the efficacy of MDSC therapies, we examined the impact of adoptive transfer of several types of MDSCs on graft rejection in ...
Published: 2021/08/01
Cited By: 0
Keywords: Myeloid-de…
National Center for Biotechnology Information
Muscle-derived Stem Cell Sheets Support Pump Function and Prevent Cardiac Arrhythmias in a Model of Chronic Myocardial Infarction
Direct intracardiac cell injection for heart repair is hindered by numerous limitations including: cell death, poor spreading of the injected cells, arrhythmia, needle injury, etc. Tissue-engineered cell sheet implantation has the potential to overcome some of these limitations. We evaluated whether...
Author: Naosumi Sekiy…
Published: 2013/03
Publication: Mol Ther. …
PubMed
The mTOR Deficiency in Monocytic Myeloid-Derived Suppressor Cells Protects Mouse Cardiac Allografts by Inducing Allograft Tolerance
Background: Myeloid-derived suppressor cells (MDSCs) can prevent allograft rejection and induce immune tolerance in transplantation models. Previous studies have demonstrated that inhibition of mTOR signaling can enhance the MDSC protective effect in heart transplantation (HTx) by promoting MDSC exp...
Author: Jiawei Li
Published: 2021/04/09
Keywords: Myeloid-de…
ScienceDirect
Ticagrelor regulates the differentiation of MDSCs after acute myocardial infarction to reduce cardiac injury
Myeloid-derived suppressor cells (MDSCs) are important participants after acute myocardial infarction (AMI), but the role of their different subtypes in AMI remains controversial. The anti-inflammatory effect of ticagrelor in AMI has been discovered. However, the detailed anti-inflammatory mechanism...
Published: 2024/03/01
Cited By: 0
Keywords: Acute myo…
National Center for Biotechnology Information
Donor myeloid derived suppressor cells (MDSCs) prolong allogeneic cardiac graft survival through programming of recipient myeloid cells in vivo
Solid organ transplantation is a lifesaving therapy for patients with end-organ disease. The Scientific Registry of Transplant Recipients (SRTR) reported that 14,313 kidney1, 7,483 liver2, 2,465 lung3, 432 heart4, 80 pancreas5, and 109 intestinal6 transplants were performed in 2017 in the US (Feb 20...
Author: Songjie Cai, J…
Published: 2020
Publication: Sci Rep. …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Blocking the A2B adenosine receptor alleviates myocardial …
Jun 8, 2022 · Myeloid-derived suppressor cell (MDSC) mobilisation is an important immune event in acute myocardial infarction (AMI). The A 2B adenosine receptor (A 2B AR) plays key role in …
- DOI: 10.1080/07853890.2022.2084153
- Published: 2022
- Publication: Ann Med. 2022; 54(1): 1616-1626.
Cell Press
https://www.cell.com › trends › endocrinology-metabolism › fulltext
Myeloid-derived suppressor cells in metabolic and cardiovascular ...
Mar 1, 2025 · We discuss growing evidence for the involvement of MDSCs in the progression of metabolic and cardiovascular diseases, with the aim of deepening our understanding of …
Nature
https://www.nature.com › articles
Donor myeloid derived suppressor cells (MDSCs) prolong ... - Nature
Aug 28, 2020 · As myeloid-derived suppressor cells (MDSCs) are potent immunoregulatory cells, we tested whether donor-derived MDSCs can protect heart transplant allografts in an antigen …
People also ask
Do MDSCs have a cardioprotective effect in heart failure models?
Notably, Zhou, L. et al. have reported that MDSCs (CD11b + Gr1 + ) show a cardioprotective effect in heart failure models through their antihypertrophic and anti-inflammatory effects 47. The differences between the two studies may be explained by the following points.
G-MDSCs promote aging-related cardiac fibrosis by activating
nature.com
What is the role of MDSCs in metabolic and cardiovascular diseases?
Understanding the molecular and cellular pathways that underpin the immunosuppressive activity of MDSCs remains an essential area of investigation. Second, the role of MDSCs in metabolic and cardiovascular diseases remains inadequately understood.
Myeloid-derived suppressor cells in metabolic and cardiovascular disord…
cell.com
Why are MDSCs important?
MDSCs have garnered significant attention in the context of cancer, infection, and pregnancy [3, 73, 74]. Recent evidence underscores their role as regulators of systemic and resident inflammation, and positions them as promising therapeutic targets for metabolic and cardiovascular diseases (Figure 1).
Myeloid-derived suppressor cells in metabolic and cardiovascular disord…
cell.com
What are myeloid-derived suppressor cells (MDSCs)?
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells that suppress innate and adaptive immunity 6, 7. MDSCs consist of two large groups of cells: granulocytic MDSCs (G-MDSCs) are phenotypically and morphologically similar to neutrophils, and monocytic MDSCs (M-MDSCs) are similar to monocytes 8.
G-MDSCs promote aging-related cardiac fibrosis by activating
nature.com
How do MDSC cells work?
MDSCs develop from common myeloid progenitor cells during the myelopoietic process and possess a powerful array of immune-suppressive mechanisms 15. These cells are recruited to inflammatory tissue to suppress acute inflammation by inhibiting the functions of innate and adaptive immunity.
G-MDSCs promote aging-related cardiac fibrosis by activating
nature.com
Are MDSCs myeloid derived cells?
Previous studies have demonstrated that MDSCs are most commonly identified by LOX or CD33 expression in humans, whereas in mice, MDSCs were found to be myeloid-derived cells (Gr1 + CD11b + ) 9, 10.
G-MDSCs promote aging-related cardiac fibrosis by activating
nature.com
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ScienceDirect
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Analysis of therapeutic potential of monocytic myeloid-derived ...
Aug 1, 2021 · In the present study, we explored the BM-MDSC populations exhibiting the most potent prolongation of transplanted heart graft survival in a mouse model. Mo-MDSCs …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Muscle-derived Stem Cell Sheets Support Pump Function and …
Jan 15, 2013 · Therefore, in this study, we sought to evaluate the use of an MDSC sheet as an optimal delivery system to further improve the regenerative capacity of MDSCs in a chronic …
PubMed
https://pubmed.ncbi.nlm.nih.gov
The mTOR Deficiency in Monocytic Myeloid-Derived Suppressor …
Apr 9, 2021 · mTOR deficiency enhances the immunosuppressive function of M-MDSCs and prolongs mouse cardiac allograft survival.
ScienceDirect
https://www.sciencedirect.com › science › article › pii
Ticagrelor regulates the differentiation of MDSCs after acute ...
Mar 1, 2024 · Therefore, this study indicated that ticagrelor treatment alleviates myocardial injury and improves cardiac contractile function by altering spleen-derived MDSC differentiation to M …
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