CCL7 is a CC chemokine also known as monocyte chemotactic protein-3 (MCP-3) that resides on chromosome 17q11.2-q12 [45]. Many studies suggest that CCL7 modulates TME and promotes tumor growth and metastasis.

MCP-3 is one of the most pluripotent chemokines since it activates all types of leukocytes, by binding to at least four different chemokine receptors. The natural protein is heterogeneous due to glycosylation and NH2-terminal processing.

The purpose of this study is to establish how MCP3 binds and activates monocytes and neutrophils. We show that human monocytes exhibit high-affinity binding for 125I-MCP3 with an estimated Kd of 1-3 nM and about 10,000 binding sites/cell.

A gene on chromosome 17q11.2-q12 that encodes monocyte chemotactic protein 3 (MCP-3), a secreted chemokine that attracts macrophages during inflammation and metastasis. MCP-3/CCL7 is a member of the C-C subfamily of chemokines, which have two adjacent cysteine residues, and is a ligand for CCR1, CCR2 and CCR3.

Monocyte chemoattractant protein-3 (MCP-3) is a chemokine encoded by the C-C motif chemokine ligand 7 (CCL7) gene (18). It is mainly expressed in monocytes, fibroblasts, and T cells. MCP-3 functions by attracting monocytes and eosinophils, but not neutrophils (19).

Dec 14, 2020 · Recent studies had identified MCP-3, IP-10, IL-6, and other cytokines as good predictors for the progression of COVID-19, while no algorism to computer the probability of ICU admission was...

May 15, 2024 · For the first time, our study identified and validated that MCP-3 could serve as a meaningful biomarker for predicting the fatal outcome of SFTS patients. The longitudinal cytokine profile analyzed that abnormally increased cytokines were associated with …

Analysis of mice lacking monocyte chemoattractant protein–1 (MCP-1), MCP-3, MCP-5, or MCP-2 plus MCP-5 revealed that MCP-3 and MCP-1 are the CCR2 agonists most critical for the maintenance of normal blood monocyte counts.

May 5, 2008 · MCP-3 was identified as a protein with monocyte chemotactic activity that copurified with MCP-1 from stimulated human osteosarcoma cells ( 36 ). MCP-3 is structurally and functionally similar to MCP-1 and is a potent in vitro chemoattractant for monocytes ( 36 ), T cells ( 37) and NK cells ( 38 ).

Monocyte Chemoattractant Protein 3 (MCP-3), also called CCL7, is produced by macrophages and some tumor cell lines. MCP-3 signals through three different G protein-coupled receptors, CCR1, CCR2, and CCR3. CCL7 chemoattracts monocytes and …