Jul 25, 2015 · The skin is largely comprised of keratinocytes within the interfollicular epidermis. Over approximately two weeks these cells differentiate and traverse the thickness of the skin.

The MAPK signaling pathway has been shown to play critical roles in epidermal differentiation and skin barrier function [20,21,22,23]. The MAPK signaling pathways can integrate and mediate various signals involved in keratinocyte differentiation, including epidermal growth factor receptor (EGFR), integrin and calcium signaling.

The central role played by the ERK/MAPK pathway downstream of RAS in human neoplasias is best exemplified in the context of melanoma skin cancer. Signaling through the MAPK pathway is crucial for the proliferation of melanocytes, the healthy pigment cells that give rise to melanoma.

Mitogen-activated protein kinases (MAPKs) are protein Ser/Thr kinases that convert extracellular stimuli into a wide range of cellular responses. MAPKs are among the most ancient signal transduction pathways and are widely used throughout …

Introduction: The role of bone marrow mesenchymal stem cells-derived exosomes (BMSCs-exo) in skin photoaging was explored in human dermal fibroblasts (HDFs). The underlying mechanism was further explored. Methods: HDFs were exposed to UVB irradiation to establish the cell photodamage models.

Apr 21, 2017 · Immunoblotting and immunohistochemistry revealed that phosphorylated-p38 MAPK was increased in the skin and epidermis of IMQ-treated mice (Figures 6a and b).

In order to mediate its effects, UV radiation is known to activate multiple signalling cascades such as the p38 MAPK, Jun N-terminal kinase, extracellular signal-regulated kinase 1/2 and NFkappaB pathways in skin cells.

Feb 21, 2025 · RHCXVII significantly inhibited the phosphorylation of p38 and c‑Jun in the MAPK and Wnt signaling pathways (P<0.01). In conclusion, RHCXVII protected skin basement membrane integrity by enhancing migration and adhesion of keratinocytes, upregulating key ECM components and inhibiting protein phosphorylation in MAPK and Wnt pathways.

Jul 10, 2013 · It has become apparent that p38 MAPK is involved in skin autoimmune diseases such as pemphigus. Nevertheless, its targeting can lead to completely unpredictable outcomes and certain adverse side effects depending on the different cells participating in …

Aug 1, 2016 · Here we show how the BRAF inhibitor vemurafenib accelerates skin wound healing by inducing the proliferation and migration of human keratinocytes through extracellular signal-regulated kinase...