Lofentanil or lofentanyl is one of the most potent opioid analgesics known and is an analogue of fentanyl, which was developed in 1960. It is most similar to the highly potent opioid carfentanil (4-carbomethoxyfentanyl), only slightly more potent.

Lofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more...

Lofentanil | C25H32N2O3 | CID 65499 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

May 3, 2017 · Lofentanil (Fig. 2 c) is another highly potent fentanyl analogue, lofentanil activates both the G protein and β-arrestin pathways and, in fact, displays bias for β-arrestin1/2 relative to DAMGO and in comparison to Gα i1, Gα i2, Gα i3, Gα oA and Gα oB [65].

Lofentanil is a pure mu-opioid receptor agonist derived from fentanyl. It is the most potent opioid to be administered to humans, about 500-1000 times more potent than morphine. Lofentanil provides a higher affinity quotient with longer dissociation times …

Lofentanil is a derivative of fentanyl that is currently used in clinical settings. From: What the lab can and cannot do: clinical interpretation of drug testing results [2020] more

Jan 7, 2025 · Lofentanil is an analog of fentanyl and is one of the most potent opioids available today. It displays most similarity to carfentanil (4-carbomethoxyfentanyl) and is considered to be slightly more potent than this drug.

The relative order of specificity between the five opiates was fentanyl greater than lofentanil greater than sufentanil greater than carfentanil greater than alfentanil. These results are discussed in the context of the search for a safe and sufficiently long …

Lofentanil is another highly potent fentanyl analogue, lofentanil activates both the G protein and β-arrestin pathways and, in fact, displays bias for β-arrestin1/2 relative to DAMGO and in comparison to Gα i1, Gα i2, Gα i3, Gα oA and Gα oB .

The efficacy and safety of IM lofentanil, the most potent morphinomimetic drug available, for rapid control of postoperative pain was compared with IM piritramide and placebo in a study of 120 patients.