SENP (sentrin/SUMO-specific protease) regulates precursor processing and deconjugation of SUMO to control cellular mechanisms. SENP3, which is one of the SENP family members, deconjugates target proteins to alter protein modification.

Jul 31, 2014 · The known SUMO-specific isopeptidases and proteases are cysteine proteases that are classified into three distinct families: the Ulp/SENP (ubiquitin-like protease/sentrin-specific protease) family, the Desi (deSUMOylating isopeptidase) family and USPL1 (ubiquitin-specific peptidase-like protein 1).

Mar 20, 2018 · We focus on SENP-controlled processes that are experimentally validated by phenotypes observed upon genetic or siRNA-mediated inactivation of a given SENP in cell culture or in animal models. In some cases, these phenotypes have been linked to impaired deSUMOylation of distinct targets.

Mar 20, 2018 · Cysteine proteases of the sentrin-specific protease (SENP) family reverse SUMO conjugation in mammalian cells. In this Cell Science at a Glance article and the accompanying poster, we will summarize how the six members of the mammalian SENP family orchestrate multifaceted deconjugation events to coordinate cell processes, such as gene ...

Sep 22, 2023 · We find that SENP6 deconjugates SUMO2/3 polymers on a group of DNA damage response proteins, including BRCA1-BARD1, 53BP1, BLM and ERCC1-XPF. SENP6 maintains these proteins in a hypo-SUMOylated...

Aug 8, 2018 · Here we show SUMO-specific protease 3 (SENP3) is a pivotal regulator of Treg cells that functions by controlling the SUMOylation and nuclear localization of BACH2. Treg cell-specific...

Six SENP isoforms (SENP1, SENP2, SENP3, SENP5, SENP6 and SENP7) have been identified in mammals. These six SENPs can be divided into three sub-families based on their sequence homology, substrate specificity and subcellular localization as shown in Table 1 [4,17–21].

Here we identify different mechanistic roles for deSUMOylation in homologous recombination (HR) and nonhomologous end joining (NHEJ) through the investigation of the deSUMOylase SENP2. We found that regulated deSUMOylation of MDC1 prevents excessive SUMOylation and its RNF4-VCP mediated clearance from DSBs, thereby promoting NHEJ.

Sep 4, 2019 · In mammalian cells two members of the SUMO specific protease (SENP) family, SENP6 and SENP7, are responsible for the depolymerization of SUMO chains 22,23. These proteases predominantly localize...

SENPs are proteases that participate in the regulation of SUMOylation by generating mature small ubiquitin-related modifiers (SUMO) for protein conjugation (endopeptidase activity) and removing conjugated SUMO from targets (isopeptidase activity).