Mar 14, 2016 · Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid antigens and are enriched in microvascular compartments of the liver. NKT cells can be activated by self- or ...

Nov 10, 2020 · To investigate the heterogeneity of NKT cells, we chose NKT cells from the liver, the peripheral organ with the highest frequency of NKT cells in mice, for single-cell RNA sequencing.

Hepatic lymphocytes are enriched in NK and NKT cells that play important roles in antiviral and antitumor defenses and in the pathogenesis of chronic liver disease. In this review, we discuss the differential distribution of NK and NKT cells in mouse, rat, …

In this review, we will discuss the distinguishing characteristics of mouse liver NK/NKT cells and discuss findings about the roles of NK/NKT cells in liver injury, fibrosis, and repair in rodent models.

Natural killer T (NKT) cells are innate-like lymphocytes that generally recognize lipid antigens and are enriched in microvascular compartments of the liver. NKT cells can be activated by self- or microbial-lipid antigens and by signaling through ...

The liver is an organ that has the largest amount of natural killer T(NKT) cells, which play critical roles in the pathogenesis of liver diseases. In this article, the authors summarize recent findings about the roles of NKT cells in liver injury, inflammation, fibrosis, regeneration and cancer.

Oct 26, 2022 · The interactions between NKT and T cells play a pivotal role in liver diseases. For example, during HBV infection in a transgenic mouse model, NKT cells promotes the proliferation of HBV-specific CD8+ T cells (112), and blockade of NKG2D expression prevents hepatitis induced by T cells (113).

Natural killer T cells are innate-like and tissue-resident lymphocytes, which recognize lipid antigens and are enriched in the liver. Natural killer T cells play important roles in infections, tumors, autoimmune diseases, and metabolic diseases. In this study, we summarize recent findings on biology …

Jun 26, 2018 · The role of iNKT cells in autoimmune liver disease (AiLD) has not been extensively studied. This review discusses the current data with regard to iNKT cells function in AiLD, in addition to providing an overview of iNKT cells function in …

Jun 11, 2015 · The liver is the organ with the highest number of natural killer T(NKT) cells, which play critical roles in the pathogenesis of liver diseases. NKT cells accelerate liver injury by producing proinflammatory cytokines and killing hepatocytes directly.