LXRS and FXR: the yin and yang of cholesterol and fat metabolism
Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively. In response to their ligands, these …
Coordinated Actions of FXR and LXR in Metabolism: From …
The mechanism in coordinated control of nuclear receptors FXR and LXR to keep bile acid levels under restraint has been reviewed by Lu et al. . In response to elevated levels of cholesterol, …
Liver X receptor - Wikipedia
The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors …
Evolution of promiscuous nuclear hormone receptors: LXR, FXR, …
One common feature of LXR, FXR, VDR, PXR, and CAR is that all receptors are activated (or, in the case of some CARs, repressed) by products of cholesterol: oxysterols (LXR), bile salts …
Natural products as modulators of the nuclear receptors and …
Nov 1, 2018 · This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X …
Transcriptional integration of metabolism by the nuclear sterol ...
Mar 14, 2012 · Liver X receptor (LXR) and farnesoid X receptor (FXR) form a heterodimer with retinoid X receptor (RXR) and mediate changes in gene expression following activation by …
BPS2025 - Functional divergence of FXR and LXR from their …
Feb 13, 2025 · Farnesoid X receptor (FXR) and liver X receptor (LXR) are transcription factors that belong to the nuclear receptor superfamily. Together, they maintain a finely tuned …
BAREing it all: the adoption of LXR and FXR and their roles in ... - PubMed
In this review we emphasize i) the role of LXR in controlling many aspects of cholesterol and fatty acid metabolism, ii) the expanded role of FXR in regulating genes that control not only bile …
Transcriptional Regulation of Metabolic Pathways via Lipid …
In the fed state, PPARs, FXR, and LXR are involved in nutrient absorption from the gut and distribution from the gut/liver to peripheral tissues (white adipose tissue and muscles). BAs …
Transcriptional integration of metabolism by the nuclear sterol ...
LXR and FXR in atherosclerosis. Agonists of both LXR and FXR exert anti-atherosclerotic effects in mouse models. LXR activation with GW3965 strongly attenuates atherosclerosis in the two …