Liver X receptors (LXRs) and farnesoid X receptor (FXR) are nuclear receptors that function as intracellular sensors for sterols and bile acids, respectively. In response to their ligands, these receptors induce transcriptional responses that maintain a …

The mechanism in coordinated control of nuclear receptors FXR and LXR to keep bile acid levels under restraint has been reviewed by Lu et al. . In response to elevated levels of cholesterol, LXRs bind the ligands and upregulate the expression of CYP7A1.

The liver X receptor (LXR) is a member of the nuclear receptor family of transcription factors and is closely related to nuclear receptors such as the PPARs, FXR and RXR. Liver X receptors (LXRs) are important regulators of cholesterol, fatty acid, and glucose homeostasis.

One common feature of LXR, FXR, VDR, PXR, and CAR is that all receptors are activated (or, in the case of some CARs, repressed) by products of cholesterol: oxysterols (LXR), bile salts (FXR, VDR, PXR), steroid hormones (PXR, CAR, FXRβ), or vitamin D (VDR).

Nov 1, 2018 · This review aims to briefly summarize current basic knowledge regarding the liver X (LXR) and farnesoid X receptors (FXR) that form permissive heterodimers with retinoid X receptors (RXR). Natural product-based ligands for these receptors are summarized and the potential of LXR, FXR and RXR as targets in precision medicine is discussed.

Mar 14, 2012 · Liver X receptor (LXR) and farnesoid X receptor (FXR) form a heterodimer with retinoid X receptor (RXR) and mediate changes in gene expression following activation by their natural ligands,...

Feb 13, 2025 · Farnesoid X receptor (FXR) and liver X receptor (LXR) are transcription factors that belong to the nuclear receptor superfamily. Together, they maintain a finely tuned regulation of whole body cholesterol homeostasis through a coordinated regulation of genes involved in glucose and lipid metabolism.

In this review we emphasize i) the role of LXR in controlling many aspects of cholesterol and fatty acid metabolism, ii) the expanded role of FXR in regulating genes that control not only bile acid metabolism but also lipoprotein metabolism, and iii) the regulation of bile acid transport/metabolism in response to bile acid-activated PXR.

In the fed state, PPARs, FXR, and LXR are involved in nutrient absorption from the gut and distribution from the gut/liver to peripheral tissues (white adipose tissue and muscles). BAs activate intestinal FXR, abetting nutrient acquisition and gut microbiota homeostasis.

LXR and FXR in atherosclerosis. Agonists of both LXR and FXR exert anti-atherosclerotic effects in mouse models. LXR activation with GW3965 strongly attenuates atherosclerosis in the two most common models — the Apoe-null mouse and the Ldlr-null mouse 105.