The prognostic value of Ki-67 in nasopharyngeal carcinoma (NPC) was controversial according to previous studies. We aimed to clarify the association between K-67 expression and survival in NPC through meta-analysis.

We found that the Ki-67 index showed significant prognostic efficiency in different survival endpoints, including OS, PFS, and DMFS, suggesting that Ki-67 could be validated as a useful index in the prognostication of patients with NPC.

May 28, 2021 · We conducted a meta-analysis to explore the potential prognostic effect of Ki-67 on overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) in NPC.

Jul 5, 2018 · According to our research, Ki67 expression levels and the dNLR are promising independent prognostic factors in NPC, and the combination of these two parameters predicted poor clinical outcomes. NPC patients with high Ki67 expression and/or a high dNLR may require more aggressive therapies, such as adjuvant therapy and targeted therapy.

Sep 20, 2020 · Ki-67 should be recommended as a useful index for prognostication in patients with NPC. This meta-analysis demonstrated that Ki-67 overexpression was a significant marker for poor prognosis in patients with NPC.

Nov 27, 2024 · The Ki-67 index is linked to the prognosis of patients with NPC, which may explain why radiomic features reflecting tumor heterogeneity can predict the Ki-67 expression level in patients with NPC. This study had certain limitations.

Dec 20, 2024 · Our study developed and validated an MRI-based radiomics nomogram for preoperative evaluation of Ki-67 expression levels in nasopharyngeal carcinoma (NPC). Methods: In all, 133 patients with pathologically-confirmed (post-operatively) NPC who underwent MRI examination in one of two medical centers.

Ki-67 is an effective indicator of tumor proliferation, invasion, and prognosis (4-7). A higher Ki-67 level means faster proliferation of cells in NPC, which requires a more abundant blood supply. In this study, BF was positively correlated with Ki-67 in NPC.

Dec 20, 2024 · Ki-67 expression in patients with N PC before they undergo surgery. Radiomics is a new research methodology that allows the extraction of a large amount of imaging features in a high

Nov 1, 2021 · LA-NPC patients with higher expression of Ki-67 (> 50%) can have a better survival outcome after neoadjuvant chemotherapy. The expression level of Ki-67 was a potential marker for predicting the efficacy of neoadjuvant chemotherapy in LA-NPC.