Inbred strains (also called inbred lines, or rarely for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding.

Charles River provides high-quality, inbred mouse models. Inbred mice strains are defined as colonies produced by a minimum of 20 generations of brother-sister mating, traceable to a single founding pair.

All of the standard JAX ® Mice inbred strains have far surpassed 20 generations of inbreeding. Except for the sex difference, mice of an inbred strain are as genetically alike as possible, being homozygous at virtually all of their loci.

Inbred strains of mice are powerful tools for use in the study of the genetics of complex disease, since each mouse of a given strain represents essentially an identical twin of all other mice in that strain.

Inbred mice can no longer be considered as completely isogenic, but provide a remarkably homogeneous animal model with an inevitable moderate-to-low degree of genetic variability.

Jun 3, 2019 · First developed about a century ago, inbred mice are created through careful breeding regimens within family groups over many generations. The result is many mice with very similar genomes, though researchers have to be careful, …

Mar 6, 2025 · This page provides access to searchable, hypertext listings of inbred strains of mice and inbred strains of rats. Both sets of information were provided by Dr. Michael FW Festing (MRC Toxicology Unit) and were converted for Web presentation by the Mouse Genome Informatics Group at The Jackson Laboratory.

Aug 31, 2020 · For over a century, inbred mice have been used in many areas of genetics research to gain insight into the genetic variation underlying traits of interest.

C57BL is probably the most widely used of all inbred strains, (substrain C57BL/6 alone accounts for over 14% of occasions on which an inbred strain is used) though in many ways it seems to be atypical of inbred strains of laboratory mice.

Charles River’s inbred strains are bred under the IGS program to help minimize subline divergence due to genetic drift and prevent genetic contamination by mismatings with other strains.