Homodimeric alpha chains (IL2RA) result in low-affinity receptor (K d ~10−8M) with no signalling ability, while dimeric beta (IL2RB) and gamma chains (IL2RG) produce a medium-affinity receptor (K d ~10−9M).

Dec 25, 2024 · IL2RA (Interleukin 2 Receptor Subunit Alpha) is a Protein Coding gene. Diseases associated with IL2RA include Immunodeficiency 41 With Lymphoproliferation And Autoimmunity and Type 1 Diabetes Mellitus 10. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and TGF-Beta Pathway.

Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis.

The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.

Elevated levels of soluble interleukin-2 receptor α-chain (IL-2Ra/CD25) are detected in the serum of patients with a broad spectrum of conditions associated with T- or B-cell immune activation, including infections, inflammation, lymphomas, and autoimmune disease. 1 For some of these conditions, measurement of IL-2Ra/CD25 levels is used in ...

Aug 7, 2023 · Here we show that both wild-type (IL-2 wt) and IL-2Rβγ-attenuated (IL-2 α-bias) agonists that preserve IL-2Rα (CD25) activities can effectively expand tumor-specific CD8 + T cells (TSTs)...

Aug 8, 2018 · IL-2 interacts with three classes of IL-2 receptor with different affinities for IL-2; IL-2 binds with low affinity (Kd ~10 −8 M) to receptors containing only IL-2Rα, with intermediate...

Jan 4, 2025 · Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis.

The IL2RA gene encodes the alpha subunit of the cell surface receptor for the T-cell growth factor interleukin-2 (IL2; 147680). The IL2 receptor is a heterotrimer of IL2RA, IL2RB (146710), and IL2RG (308380) and plays a vital role in maintaining the immune system.

We develop a pro-grammed cell death protein 1 (PD-1)-targeted, receptor-masked IL-2 immunocytokine, PD1-IL2Ra-IL2, which attenuates systemic IL-2 activity while maintaining the capacity to engage IL-2R on PD-1+T cells.