Feb 20, 2025 · Title: Detection rate of IGF-1 variants and their implication to protein binding: study of over 240,000 patients. Compression Promotes the Osteogenic Differentiation of Human Periodontal Ligament Stem Cells by Regulating METTL14-mediated IGF1.

The findings indicated that miR-135a promotes cell apoptosis and inhibits cell proliferation, migration, invasion and tumor angiogenesis by targeting IGF-1 gene through the IGF-1/PI3K/Akt signaling pathway in non-small cell lung cancer.

The IGF-1 is a single gene consisting of six exons spanning nearly 90 kb of genomic DNA. The exons are alternatively spliced to generate multiple transcripts each encoding a different pre-pro-IGF-I protein possessing variable signaling peptide leader sequences.

Feb 11, 2025 · NK cell potentiation by G-F1 was antagonized by insulin-like growth factor (IGF)-1 blockade and recapitulated by IGF-1 treatment, suggesting the involvement of IGF-1. These data demonstrate a specific role for IGF-I in maintaining muscle homeostasis in adults.

The insulin-like growth factor 1 receptor (IGF-1R) gene was found to be a potential downstream target of NUCKS1 in GC cells. In stressed corneal epithelial cells IGFBP-3 functions as a caretaker to maintain levels of IGF-1R in the nucleus.

The human IGF-1 receptor (type 1 receptor) is the product of a single copy gene spanning over 100 kb of genomic DNA at the end of the long arm of chromosome 15q25–26. 22 The gene contains 21 exons (fig 2 ) and its organisation resembles that of the structurally related insulin receptor (fig 3 ). 23 The type 1 IGF receptor gene is expressed by ...

Oct 10, 2024 · Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.

Sep 14, 2016 · Gene target information for IGF1 - insulin like growth factor 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

IGF-1 regulates normal growth during childhood and may exert a strong anabolic effect in adults. In its extremes, absence or excess of IGF-1 results in serious growth abnormalities, especially in children. IGF-1 is down-regulated in T1DM but is up-regulated in T2DM.

Detailed genetic analysis and functional experiments have shown that IGF-1 plays a key role in pre- and postnatal growth and development in human. Eleven patients with heterozygous and 2 patients with compound heterozygous mutations in the …