The role of insulin-like growth factor-1 in bone remodeling: A
May 31, 2023 · Insulin-like growth factor (IGF)-1 is a polypeptide hormone with vital biological functions in bone cells. The abnormal expression of IGF-1 has a serious effect on bone …
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting …
Circulating levels of IGF-1 directly regulate bone growth and density
Circulating levels of IGF-1 appear to play a major role in bone remodeling and have a direct impact on linear bone growth, as shown by various skeletal parameters evaluated in this …
The role of insulin-like growth factor-1 in bone ... - ScienceDirect
May 31, 2023 · Insulin-like growth factor (IGF)-1 is a polypeptide hormone with vital biological functions in bone cells. The abnormal expression of IGF-1 has a serious effect on bone …
Bone marrow-derived IGF-1 orchestrates maintenance and
Jan 3, 2023 · Here, we show that BM stromal cells (BMSCs) and megakaryocytes/platelets (MKs/PLTs) express the highest levels of IGF-1 in adult long bones. Deletion of Igf1 from …
Function of Matrix IGF-1 in Coupling Bone Resorption and …
Insulin-like growth factor type 1 (IGF-1) has long been known to play a role in bone strength. It is one of the most abundant substances in the bone matrix, circulates systemically and is …
Effect of GH/IGF-1 on Bone Metabolism and Osteoporsosis
Growth hormone (GH) and insulin-like growth factor (IGF-1) are fundamental in skeletal growth during puberty and bone health throughout life. GH increases tissue formation by acting …
The Insulin-Like Growth Factor System in Bone - PMC
The insulin-like growth factor (IGF) regulatory system consists of IGFs (IGF-I and IGF-II), IGF receptor, and regulatory proteins including IGF-binding proteins (IGFBP-1 to IGFBP-6) and the …
The role of insulin-like growth factor-1 in bone ... - ScienceDirect
May 31, 2023 · Insulin-like growth factor (IGF)-1 is a polypeptide hormone with vital biological functions in bone cells. The abnormal expression of IGF-1 has a serious effect on bone …
IGF-1 regulation of key signaling pathways in bone - PMC
Insulin-like growth factor 1 (IGF-1) is important for a number of different growth and differentiation processes across a wide variety of tissues. 1 Specifically, the growing skeleton is modulated …