Jun 16, 2023 · Our data showed that glycolytic ATP production output increases in BC cells due to IGF-1. This finding implies that IGF-1/IGF-1R interaction assists BC cells in meeting the metabolic demand for proliferation via glycolysis.

Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. [5]

Jun 16, 2023 · Treating MCF-7L cells with 5 nM IGF-1 increased the glycolytic ATP production rate, while 10 nM insulin did not affect metabolism when compared with the control. Neither treatment altered ATP production in MCF-7L TamR cells. This study provides evidence of the relationship between metabolic dysfunction, cancer, and the IGF axis.

Nov 1, 2021 · IGF-1 suppresses hypotonic stimulation of the TRPV4 channel to reduce Ca 2+ influx in ATDC5 cells. IGF-1 stimulates the f-actin stress fiber formation which binds to the TRPV4 MAP7 binding domain to elicit this suppression. Mutation of the MAP7 site abrogates the response of cells to IGF-1.

To unveil the effects of IGF-1 on the energetic state of cardiomyocytes under NS, we quantified intracellular ATP levels. We observed that NS significantly decreased intracellular ATP content, and treatment with IGF-1 rescued ATP levels significantly (Figure 3C).

IGF-1 availability is tightly regulated by the so-called insulin-like growth factor binding proteins (IGFBPs), which may act by increasing IGF-1 half-life, from minutes to hours (most commonly by forming a tertiary complex with Acid-Labile Subunit and IGFBP3), however blocking its binding to the insulin-like growth factor 1 receptor (IGF-1R ...

ATP-binding cassette transporter A1 (ABCA1) in pancreatic beta cells influences insulin secretion and cholesterol homeostasis. The present study investigates whether insulin-like growth factor 1 (IGF-1), which mediates stimulation of ABCA1 gene expression, could also interfere with the phosphatidyli …

Feb 3, 2016 · IGF-1R tone buffers resting Ca 2+ and maintains ATP levels during spiking activity. The insulin-like growth factor-1 receptor (IGF-1R) signaling is a key regulator of lifespan, growth, and development.

Jun 16, 2023 · Treating MCF-7L cells with 5 nM IGF-1 increased the glycolytic ATP production rate, while 10 nM insulin did not affect metabolism when compared with the control.

Jun 16, 2023 · IGF-1 Stimulates Glycolytic ATP Production in MCF-7L Cells. International Journal of Molecular Sciences , 24 (12), 10209. https://doi.org/10.3390/ijms241210209