Isocitrate dehydrogenase 1 - Wikipedia
Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative …
IDH1 Gene - GeneCards | IDHC Protein | IDHC Antibody
Dec 25, 2024 · IDH1 (Isocitrate Dehydrogenase (NADP (+)) 1) is a Protein Coding gene. Diseases associated with IDH1 include Enchondromatosis, Multiple, Ollier Type and Multiple …
IDH1 gene - MedlinePlus
The IDH1 gene provides instructions for making an enzyme called isocitrate dehydrogenase 1. Learn about this gene and related health conditions.
IDH1 isocitrate dehydrogenase (NADP(+)) 1 [ (human)]
IDH1 gene mutation is associated with blast-phase myeloproliferative neoplasms. Less than half of patients with cytogenetically normal acute myeloid leukemia with elevated 2 …
IDH1 mutations are present in the majority of common adult …
In this study, we carried out an extensive screening for mutations of exon 4 of the IDH1 gene in a large series of human brain tumors. We identified a high frequency of IDH1 mutations in the …
IDH1 : Linking Metabolism and Epigenetics - PubMed Central (PMC)
Gain of function mutations in IDH1 or IDH2 result in reduced levels of α-KG as a result of increased formation of D-2-Hydroxyglutarate (2-HG). α-KG is an essential co-factor for certain …
IDH1 isocitrate dehydrogenase (NADP(+)) 1 - NIH Genetic …
Feb 9, 2025 · The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal …
The implications of IDH mutations for cancer development and …
Jun 15, 2021 · Mutations in the genes encoding the cytoplasmic and mitochondrial forms of isocitrate dehydrogenase (IDH1 and IDH2, respectively; collectively referred to as IDH) are …
IDH1 isocitrate dehydrogenase (NADP(+)) 1 [Homo sapiens (human)] - Gene ...
Feb 9, 2025 · The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal …
Definition of IDH1 gene - NCI Dictionary of Cancer Terms
A gene that makes a protein that helps break down fats for energy and protect cells from harmful molecules. Mutations (changes) in the IDH1 gene have been found in several genetic …