ICAM-1 is a transmembrane protein possessing an amino-terminus extracellular domain, a single transmembrane domain, and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein’s extracellular domain is composed of multiple loops created by disulfide bridges within the

ICAM-1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM-1 expression is also robustly ...

Dec 25, 2024 · ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

Sep 15, 2024 · Intercellular adhesion molecule 1 (ICAM-1/CD54), a transmembrane glycoprotein, has been considered as one of the most important adhesion molecules during leukocyte recruitment. It is encoded by the ICAM1 gene and plays a central role in inflammation.

In their paper, Sumagin et al. have examined the role of ICAM-1 and the possible role of a leukocyte-endothelium interaction in the regulation of vascular permeability. During inflammation development, two major events occur.

ICAM-1 mediates the adhesion and infiltration of leucocytes by recognition with the ligand lymphocyte function-associated antigen-1 (LFA-1). In addition, the ICAM-1/LFA-1 interaction plays an important role in the formation of the immunological synapse between T cells and APCs.

Nov 1, 2024 · ICAM-1 not only regulates the antitumor toxicity of immune effector cells, but also plays a vital role in tumor immune evasion. Decreased ICAM-1 expression on the surface of tumor cells contributes to reduced immunogenicity, forming the …

May 15, 2014 · ICAM-1 is an iconic marker of inflammation in EAE and multiple sclerosis, with elevated expression at lesion sites on endothelial cells and on infiltrating and resident CNS cells (7, 57, 58).

Jun 5, 2024 · Humans generate the protein ICAM-1, also known as CD54, or intercellular adhesion molecule-1. The ICAM-1 gene produces this protein. ICAM-1 is an Ig superfamily member consisting of five extracellular Ig domains, a transmembrane domain, and a short cytoplasmic region.

Aug 1, 2023 · Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) belong to the immunoglobulin superfamily of cell adhesion molecules (CAM) with a crucial role in mediating the strong adherence of leukocytes to endothelial cells in numerous acute as well as chronic diseases.