The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, is a signaling pathway that controls organ size in animals through the regulation of cell proliferation and apoptosis.

Dec 13, 2018 · Here, we review the role of Hippo signalling in animal regeneration, examine the promises and risks of YAP/TAZ activation for regenerative medicine and discuss strategies to activate YAP/TAZ for...

Nov 8, 2022 · Here, we review the key components and upstream signals of the Hippo pathway, as well as the critical physiological functions controlled by the Hippo pathway. Additionally, diseases associated...

Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration.

When localized to the nucleus, Yap/Taz interact with TEAD transcription factors to induce transcriptional programs of proliferation, stemness, and growth. In the cytoplasm, Yap/Taz interact with multiple pathways to regulate a variety of cellular functions or are targeted for degradation.

Mar 7, 2024 · In this review, we aim to provide a timely update on the molecular organization and regulatory mechanisms of the mammalian Hippo pathway and discuss its roles in the development and regeneration of several organs. The core Hippo signaling pathway is highly conserved in Drosophila and mammals.

Here, we review the role of Hippo signalling in animal regeneration, examine the promises and risks of YAP/TAZ activation for regenerative medicine and discuss strategies to activate YAP/TAZ for regenerative therapy while minimizing adverse side effects.

YAP/TAZ are well known for being the effectors of the Hippo signaling cascade, and mouse mutants in Hippo pathway components display remarkable phenotypes of organ overgrowth, enhanced stem cell content and reduced cellular differentiation.

Mar 1, 2025 · Physiological functions of the Hippo pathway. The YAP/TAZ-TEAD transcriptional complex integrates diverse upstream signals to regulate fundamental cellular processes, including proliferation, apoptosis, differentiation, stemness, and cellular mechanics.

Aug 18, 2022 · The Hippo-YAP pathway regulate the inflammation response in heart failure and cardiomyopathy. YAP increases the accumulation of inflammatory cells and impairs cardiac function in chronic pressure overload while hardly affects the accumulation of inflammatory cells in acute pressure overload.