HLA-DQ8 (DQ8) is a human leukocyte antigen serotype within the HLA-DQ (DQ) serotype group. DQ8 is a split antigen of the DQ3 broad antigen. DQ8 is determined by the antibody recognition of β 8 and this generally detects the gene product of DQB1*0302. DQ8 is commonly linked to autoimmune disease in the human population.

Aug 22, 2022 · As a unique serotype, HLA-DQ8 is most commonly linked to autoimmune diseases including celiac disease, rheumatoid arthritis, and juvenile diabetes. For reasons unknown, this gene can turn the body's defenses against itself, directing the immune system to attack and destroy its own cells.

Aug 18, 2009 · I have monoclonal gammopathy (paraproteinemia), limited systemic scleroderma, Hashimoto's thyroiditis, obstructive sleep apnea, beginning neuropathy, and have just been found to have the celiac HLA type: DQ8.

The HLA gene alleles that predispose a person to celiac disease are called DQ2 and DQ8. One may have DQ2 or DQ8 in one of the copies or in both. People who have only one copy of DQ2 or DQ8 have a risk of about 3% of having celiac disease, whereas people who have two copies of either have a risk ~10%.

Genetic testing for human leukocyte antigens (HLA-DQ2 and HLA-DQ8) can be used to rule out celiac disease. It's important to be tested for celiac disease before trying a gluten-free diet. Eliminating gluten from your diet might make the results of blood tests appear in …

Carrying HLA DQ2 and/or DQ8 is not a diagnosis of celiac disease nor does it mean you will ever develop celiac disease. However, if you carry HLA DQ2 and/or DQ8, your risk of developing celiac disease is 3% instead of the general population risk of 1%.

Sep 3, 2019 · HLA-DQ2 and DQ8 are found to play important roles in the development of celiac disease. HLA-DQ2 and DQ8 can uniquely present specific gluten-derived peptides, compared with other HLA types that cannot. Inflammation is triggered by a pathogenic process in which antigen-presenting cells present deamidated gluten that binds to HLA-DQ2 or DQ8.

Individuals expressing HLA-DQ2 or DQ8, and DQ2/8 trans-dimers, have elevated risk for type 1 diabetes (T1D). Cells co-expressing DM with these DQ molecules were observed to express elevated levels of CLIP (Class II associated invariant chain peptide).

The HLA-DQ2 and HLA-DQ8 genotyping can be beneficial for accurate diagnosis, particularly in areas with poor awareness and diagnostic aptitude. In interior Sindh population, celiac patients had DQ2 (85.7%), DQ8 (11.4%), and DQ2/DQ8 (2.8%).

The presence of HLA DQ2 and DQ8 was identified in 98,4% of 74 celiac patients, of which 79,7% had only HLA DQ2; 8,1% had only HLA DQ8 and 10,8% had both antigens histocompatibility. In the group of relatives of celiac patients, were included 29 patients; among them, 89,6% had HLA DQ2 and/or DQ8; 76% only the HLA DQ2, 10,3% only HLA DQ8 and 3,4% ...