
Biological Phenotypes of Heart Failure With Preserved Ejection ...
Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials.
Heart Failure With Preserved Ejection Fraction: JACC Scientific ...
Apr 19, 2023 · In this JACC Scientific Statement, we provide an in-depth and updated examination of the epidemiology, pathophysiology, diagnosis, and treatment of HFpEF. HFpEF is an increasingly common cause of exercise intolerance linked to obesity and sedentary behavior.
Current Understanding of Molecular Pathophysiology of Heart …
While the ECM-based changes are likely to be the main factor in the advanced stages of the disease, the cardiomyocyte-based changes occur in the early stages of HFpEF (Franssen and González Miqueo, 2016). A common structural myocardial change is LV hypertrophy.
Targeting heart failure with preserved ejection fraction: current ...
Heart failure with preserved ejection fraction (HFpEF) portrays a significant burden in terms of prevalence, morbidity, mortality, and health care costs. There is a lack of consensus on the basic pathophysiology, definition, and therapeutic targets for therapy for this syndrome.
2023 ACC Expert Consensus on Management of HFpEF: Key Points
Apr 19, 2023 · Heart failure with preserved ejection fraction (HFpEF) is defined as signs and symptoms of HF with left ventricular EF (LVEF) ≥50%. Diagnosis and management of HFpEF needs multidisciplinary care involving primary care, cardiology, and HF specialists.
Atrial Fibrillation (AF) and Heart Failure With Preserved Ejection ...
Mar 10, 2025 · HFpEF was defined until recently as a clinical syndrome with symptoms and/or signs of HF and a left ventricular (LV) ejection fraction (EF) measurement of ≥ 45%. ... promoting the deposition of ECM proteins and collagen. Endothelial dysfunction also impairs paracrine signaling of CMECs to cardiomyocytes. Cardiomyocyte remodeling is also ...
Heart Failure with Preserved Ejection Fraction: Emerging Drug ...
Approximately half of heart failure patients have a normal ejection fraction, a condition designated as heart failure with preserved ejection fraction (HFpEF). This heart failure subtype disproportionately affects women and the elderly and is ...
The role of titin and extracellular matrix remodelling in heart …
Heart failure with preserved ejection fraction (HFpEF) is characterised by a high incidence of metabolic comorbidities that share the potential to induce both systemic and coronary microvascular inflammation and oxidative stress.
Biological Phenotypes of Heart Failure With Preserved Ejection Fraction
Oct 24, 2017 · Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials.
ESC Consensus on HFpEF Diagnosis: Key Points
Oct 28, 2019 · A score of ≥5 based on echocardiographic and natriuretic peptide levels is diagnostic of HFpEF. A score of ≤1 makes a diagnosis of HFpEF very unlikely. For a score of 2-4 points, additional workup in the form of diastolic stress echocardiography is recommended.
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