Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials.

Apr 19, 2023 · In this JACC Scientific Statement, we provide an in-depth and updated examination of the epidemiology, pathophysiology, diagnosis, and treatment of HFpEF. HFpEF is an increasingly common cause of exercise intolerance linked to obesity and sedentary behavior.

While the ECM-based changes are likely to be the main factor in the advanced stages of the disease, the cardiomyocyte-based changes occur in the early stages of HFpEF (Franssen and González Miqueo, 2016). A common structural myocardial change is LV hypertrophy.

Heart failure with preserved ejection fraction (HFpEF) portrays a significant burden in terms of prevalence, morbidity, mortality, and health care costs. There is a lack of consensus on the basic pathophysiology, definition, and therapeutic targets for therapy for this syndrome.

Apr 19, 2023 · Heart failure with preserved ejection fraction (HFpEF) is defined as signs and symptoms of HF with left ventricular EF (LVEF) ≥50%. Diagnosis and management of HFpEF needs multidisciplinary care involving primary care, cardiology, and HF specialists.

Mar 10, 2025 · HFpEF was defined until recently as a clinical syndrome with symptoms and/or signs of HF and a left ventricular (LV) ejection fraction (EF) measurement of ≥ 45%. ... promoting the deposition of ECM proteins and collagen. Endothelial dysfunction also impairs paracrine signaling of CMECs to cardiomyocytes. Cardiomyocyte remodeling is also ...

Approximately half of heart failure patients have a normal ejection fraction, a condition designated as heart failure with preserved ejection fraction (HFpEF). This heart failure subtype disproportionately affects women and the elderly and is ...

Heart failure with preserved ejection fraction (HFpEF) is characterised by a high incidence of metabolic comorbidities that share the potential to induce both systemic and coronary microvascular inflammation and oxidative stress.

Oct 24, 2017 · Heart failure with preserved ejection fraction (HFpEF) involves multiple pathophysiological mechanisms, which result in the heterogeneous phenotypes that are evident clinically, and which have potentially confounded previous HFpEF trials.

Oct 28, 2019 · A score of ≥5 based on echocardiographic and natriuretic peptide levels is diagnostic of HFpEF. A score of ≤1 makes a diagnosis of HFpEF very unlikely. For a score of 2-4 points, additional workup in the form of diastolic stress echocardiography is recommended.