Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein .

肝素结合性表皮生长因子 (hb-egf) 是 egf 家族中与肝素结合的成员之一。它是成纤维细胞和平滑肌细胞有效的有丝分裂原和趋化因子。hb-egf 合成为膜锚定形式 (pro-hb-egf)，经金属蛋白酶 adam 家族处理释放可溶性成熟肽，这个过程被称为“外域脱落”。

肝素结合egf样生长因子（hb-egf）结合并激活egf受体（egfr/erbb1）和erbb4。对几种缺乏hb-egf表达的突变小鼠的研究表明，hb-egf与erbb受体一起在正常心脏功能和正常心脏瓣膜形成中起着关键作用。

Jan 1, 2018 · HB-EGF is a heparin-binding member of the EGFR ligands that was initially identified in the conditioned medium of human macrophage-like cells (Higashiyama et al. 1991). HB-EGF directly binds to and activates EGFR and ErbB4. The ErbB family of receptor tyrosine kinases (RTKs) consists of four receptors: EGFR/ErbB1, ErbB2, ErbB3, and ErbB4.

Heparin-binding EGF-like growth factor (HB-EGF) is an EGF family member that interacts with epidermal growth factor receptor (EGFR) and ERBB4. Since HB-EGF was first identified as a novel growth factor secreted from a human macrophage cell line, ...

Feb 26, 2024 · Using proteomic analyses of cerebrospinal fluid specimens from patients with MS in combination with experimental studies, we here identify Heparin-binding EGF-like growth factor (HB-EGF) as a...

Dec 25, 2024 · It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. ( HBEGF_HUMAN,Q99075 )

Sep 25, 2012 · HB-EGF has been implicated in neuronal survival, glial/stem cell proliferation, and differentiation. HB-EGF also enhances the neurite outgrowth and neuroprotection against ischemic injury in PC12 cells by activation of the MAPK signal pathway 64.

HB-EGF plays a pro-inflammatory role in the active skin and lung lesions of systemic sclerosis. HB-EGF expression in serum may be a potential therapeutic indicator for novel HB-EGF-targeted therapy in recurrent ovarian cancer. both HBEGF upregulation and apoptosis were rescued by exogenous MMP2

Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a member of the EGF family. It contains an EGF-like domain as well as a heparin-binding domain that allows for interactions with heparin and cell-surface heparan sulfate.