Granulovacuolar degeneration (GVD) is characterized by the intraneuronal accumulation of large (up to 5 µm diameter) membrane-bound vacuoles harbouring a central granule.

We explored the components of RVs by immunohistochemistry, using antibodies for GVD markers. Subjects included one AD case, eight cases of sporadic IBM, and three cases of …

Oct 30, 2024 · We confirmed their presence in GVD granules by costaining with casein kinase 1 delta (CK1δ), which is a standard marker for GVD pathology (Fig. 2, B and C) (17, 24). …

Nov 28, 2013 · Granulovacuolar degeneration (GVD) bodies are spherical vacuoles containing argentophilic and hematoxyphilic granules, and are one of the pathological hallmarks …

The resultant immunohistochemical signature suggests that granulovacuolar degeneration bodies (GVBs) do contain late-stage autophagic markers, and accumulate at the nexus of autophagic …

Jan 9, 2025 · GVB distribution was characterized via immunohistochemistry using CK1δ as the primary GVB marker. Co-staining with a phospho-tau antibody (AT8) confirmed the presence …

Several of these proteins serve as markers of GVD. Most researchers and authors have interpreted the sequestration of proteins into GVD inclusions as either a cellular defense …

Immunohistochemical analyses using isoform-selective antibodies demonstrated that MARK4 in a phosphorylated form colocalizes with p-tau Ser 262 in granulovacuolar degeneration bodies …

Oct 8, 2020 · Analyses revealed significant increases of pS65‐Ub levels in AD brain, which strongly correlated with granulovacuolar degeneration (GVD) and early phospho‐tau deposits, …

Nov 28, 2013 · We explored the components of RVs by immunohistochemistry, using antibodies for GVD markers. Subjects included one AD case, eight cases of sporadic IBM, and three …