GAB2 is a docking protein with a conserved, folded PH domain attached to the membrane and a large disordered region, which hosts interactions with signaling molecules. It is a member of the GAB/DOS family localized on the internal membrane of the cell.

Dec 25, 2024 · GAB2 (GRB2 Associated Binding Protein 2) is a Protein Coding gene. Diseases associated with GAB2 include Noonan Syndrome-Like Disorder With Loose Anagen Hair 1 and Childhood Angiosarcoma. Among its related pathways are Insulin receptor signalling cascade and FLT3 signaling in disease.

Apr 8, 2021 · Gab2 (Grb2-associated binder2) silencing or deficiency inhibits TNFα (tumor necrosis factor alpha)-induced, IL (interleukin)-1β–induced, or lipopolysaccharide (LPS)-induced proinflammatory responses in endothelial cells.

Gab2, a key member of the Gab family of proteins, is involved in the amplification and integration of signal transduction, evoked by a variety of extracellular stimuli, including growth factors, cytokines and antigen receptors.

GAB2 is essential for two major signal transduction pathways in cancer, the PI3-K-AKT and extracellular signal-regulated kinase (ERK) signaling pathways, and thus regulates a number of key cellular processes.

GAB2 is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. The docking protein Gab2 is overexpressed and estrogen regulated in human breast cancer.

Feb 8, 2025 · Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor-associated macrophages. The Gab2-MALT1 axis regulates thromboinflammation and deep vein thrombosis. Inhibition of GAB2 expression has a protective effect on osteoarthritis:An in vitro and in vivo study.

Mechanistically, we demonstrate a key role for the combined actions of Gab2-regulated PI3K-Akt and SHP2-extracellular signal-regulated kinase (Erk) axes in the expansion of MNP progenitors. Gab2 deficiency also reduces the mitogenic response to CSF-1 …

Gab2 functions to mediate the activation of critical cell signaling pathways by multiple cell surface receptors for growth factors, cytokines, antigens, and immunoglobulins (Fig. 2).

We describe a novel human adapter molecule containing a pleckstrin homolgy (PH) domain at the N terminus that is closely related to human G rb2- a ssociated b inder 1, Gab1, and Drosophila daughter of sevenless. We designate this protein as Gab2.