Feb 20, 2018 · In this study, 33/93 DLBCL cases were positive for GPX4, which was overexpressed compared with non-neoplastic B cells. The GPX4-positive group showed significantly poorer prognosis in OS and...

In this review, we first describe the structure and function of GPX4, then outline the novel roles of GPX4 in cell death and autophagy, and finally discuss the impact of GPX4 on embryonic development and disease.

GPX4 is a phospholipid hydroperoxidase that protects cells against membrane lipid peroxidation. GPX4 was first discovered in biochemistry laboratories of the University of Padua, where it was described as an enzyme capable of protecting against peroxidation.

Dec 21, 2024 · This study utilizes a doxycycline inducible GPx4 overexpression model to test this hypothesis. Consistently, the overexpression of GPx4 significantly impairs cell growth and colony formation while also causing an accumulation of cells in G1/G0 phase of the cell cycle.

Recently, GPX4 was discovered to be involved in a rare neonatal lethal disorder called Sedaghatian-type spondylometaphyseal dysplasia (SSMD). In several cases of SSMD identified to date, patients presented with a variant in GPX4.

Feb 25, 2025 · GPX4 and PC differentially affect TNBC cell response to redox stress. (A) Immunoblot analysis of control (shScram) and PC-knockdown (shPCB and shPCC) metM-Wnt lung cells probed for Nrf2 and ß-Actin (n = 6/group).(B) Percent survival of metM-Wnt lung shPC and shScramble cells treated with H 2 O 2 (500µM) for 24 h (n = 4/group).(C) Top 50 Codependencies for the gene SLC7A11 from Depmap’s ...

Feb 10, 2025 · Ferroptosis, a form of oxidative cell death mediated by lipid peroxidation, is strictly regulated by glutathione peroxidase 4 (GPX4). Knockout of Gpx4 results in embryonic lethality, highlighting its essential role in development.

Jul 8, 2024 · Rational targeting of GPX1, GPX4 and TXNRD1 holds high therapeutic potential in different pathological settings, where lipid peroxidation is either harmful or can be triggered for therapeutic purpose, as it is the case in numerous cancers and more particularly AML.

Oct 15, 2024 · In strokes, excess glutamate depletes glutathione (GSH) and products of hemoglobin breakdown overwhelm GPx4. Studies using genetic models with GPx4 deficiency underscore its vital role in maintaining neuronal survival and function.

Feb 16, 2024 · Ferroptosis execution involves membrane lipid peroxidation, leading to plasma membrane rupture and cell death. The glutathione (GSH)–glutathione peroxidase 4 (GPX4) and NADPH–ferroptosis...