Jan 10, 2025 · FtsH’s role in protein quality control is further exemplified through its interactions with cellular machinery. During times of cellular stress, FtsH collaborates with chaperones to refold proteins when possible and degrades those beyond repair.

Jan 1, 2012 · FtsH is a conserved AAA protease found in eubacteria, mitochondria and chloroplasts. As typical for AAA + proteases, bacterial FtsH forms barrel-shaped homo-hexamers. FtsH is membrane-anchored and crucial for membrane protein quality control. In E. coli, FtsH is essential due to regulation of lipopolysaccharide biosynthesis. FtsH plays a role ...

Apr 27, 2021 · FtsH belongs to the AAA+ ATP-dependent family of proteases, which participate in diverse cellular processes and are ubiquitous among bacteria, chloroplasts, and mitochondria. FtsH is poorly characterized in most organisms, especially compared to …

Apr 5, 2019 · FTSH proteases are membrane-bound, ATP-dependent metalloproteases found in bacteria, mitochondria and chloroplasts. The product of one of the 12 genes encoding FTSH proteases in Arabidopsis, FTSH11, has been previously shown to be essential for acquired thermotolerance.

The name FtsH (filamentation temperature-sensitive) erroneously originated from the growth behavior of a Y16 Escherichia coli strain deficient in its ftsh gene. However, later, a second, independent mutation was found to be responsible for the …

Aug 1, 2024 · FtsH protease plays a central role in bacterial protein quality control, safeguarding cellular functions by regulating the turnover of proteins. This protease ensures that only properly folded and functional proteins accumulate within the cell, preventing the detrimental effects of protein aggregation.

May 31, 2021 · FtsH metalloproteases found in eubacteria, animals, and plants are well-known for their vital role in the maintenance and proteolysis of membrane proteins. Their location is restricted to organelles of endosymbiotic origin, the chloroplasts, and mitochondria. In the model organism Arabidopsis tha …

FtsH degrades a set of short-lived proteins, enabling cellular regulation at the level of protein stability. FtsH also degrades some misassembled membrane proteins, contributing to their quality maintenance.

Abstract FtsH, a member of the AAA (ATPases associated with a variety of cellular activities) family of proteins, is an ATP-dependent protease of ~71 kDa anchored to the inner membrane.

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