Peptidyl-prolyl cis-trans isomerase FKBP1A is an enzyme that in humans is encoded by the FKBP1A gene. [5] . It is also commonly referred to as FKBP-12 or FKBP12 and is a member of a family of FK506 -binding proteins (FKBPs).

Dec 25, 2024 · FKBP1A (FKBP Prolyl Isomerase 1A) is a Protein Coding gene. Diseases associated with FKBP1A include Fibrodysplasia Ossificans Progressiva and Subependymal Glioma. Among its related pathways are TGF-beta receptor signaling activates SMADs and Infectious disease.

FKBP1A (also known as FKBP12) is notable in humans for binding the immunosuppressant molecule tacrolimus (originally designated FK506), which is used in treating patients after organ transplant and patients with autoimmune disorders. [3]

Upregulated FKBP1A Suppresses Glioblastoma Cell Growth via Apoptosis Pathway. The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma. FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.

Oct 24, 2022 · Liver hepatocellular carcinoma (LIHC) remains a global health challenge with poor prognosis and high mortality. FKBP1A was first discovered as a receptor for the immunosuppressant drug FK506 in immune cells and is critical for various tumors and cancers.

Dec 10, 2024 · Title: The Prognostic Significance of FKBP1A and Its Related Immune Infiltration in Liver Hepatocellular Carcinoma. FKBP1A upregulation correlates with poor prognosis and increased metastatic potential of HNSCC.

In turn, genetic knockout (KO) of FKBP prolyl isomerase 1A (FKBP1A), which encodes a protein targeted by both drugs, was necessary to confer CD19-specific CAR-T cells (19CAR) robust functional resistance to these immunosuppressants.

We demonstrated that FKBP1A was the hub gene in GBM via a weighted correlation network analysis (WGCNA) and differentially expressed genes (DEGs) analysis based on the bulk RNA-seq data from TCGA and GTEx. Afterwards, we proved that the upregulated FKBP1A protein could promote GBM cell death by CCK-8 assays in U87MG and t98g GBM cell lines.

Feb 8, 2025 · peptidyl-prolyl cis-trans isomerase FKBP1A, FK506 binding protein 12, PPIase FKBP1A, calstabin-1, immunophilin FKBP12. GeneRIFs: Gene References Into Functions. FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes.

FKBP1A was first discovered as a receptor for the immunosuppressant drug FK506 in immune cells and is critical for various tumors and cancers. However, the relationships between FKBP1A expression, cellular distribution, tumor immunity, and prognosis in LIHC remain unclear.