Nov 1, 2021 · Abstract. Diffusion MRI has provided the neuroimaging community with a powerful tool to acquire in-vivo data sensitive to microstructural features of white matter, up to 3 orders of magnitude smaller than typical voxel sizes.

Jan 28, 2022 · Fixel-based analysis (FBA) is a novel framework that addresses the shortcomings of DTI and estimates microstructural changes of individual populations of specific white matter fiber bundles on a ...

Feb 3, 2025 · MRtrix3 provides a set of tools to perform various types of diffusion MRI analyses, from various forms of tractography through to next-generation group-level analyses. It is designed with consistency, performance, and stability in mind, and …

Nov 4, 2021 · Fixel-based analysis (FBA) and free water corrected DTI (fwcDTI) have recently emerged as useful techniques to quantify abnormalities in WM. Here, we sought to evaluate FBA and fwcDTI metrics between HIV+ and healthy controls (HIV-) individuals.

This tutorial explains how to perform fixel-based analysis using MRtrix commands.

Here, we used fixel-based analysis (FBA) to investigate age-related WM differences observed using DTI in a sample of 45 older and 25 younger healthy adults. Age-related FA differences were widespread but were strongly associated with differences in multi-fiber complexity (CX), suggesting that they reflected differences in crossing fibers in ...

Nov 3, 2021 · Fixel-based analysis (FBA) and free water corrected DTI (fwcDTI) have recently emerged as useful techniques to quantify abnormalities in WM. Here, we sought to evaluate FBA and fwcDTI metrics between HIV+ and healthy controls (HIV−) individuals.

ture have been based on DTI, which provides general information on the local orientation of white matter fibres as well as metrics describ- ing the fractional anisotropy (FA) and mean diffusivity (MD). Prepro- cessing, various fitting strategies, and post-processing for DTI are well- documented (Van Hecke et al., 2015; Mori & Tournier, 2014).

DTI's limited accuracy in assessing crossing fibres prompted novel methods that distinguish fibres crossing through same voxel-spaces, such as fixel-based analysis (FBA), highlighting subtle macrostructural and microstructural alterations in AD and MCI.

May 1, 2024 · We applied fixel-based analyses (FBA) to examine microscopic differences in fiber density (FD) and macroscopic changes in fiber cross-section (FC) in early stages of AD (N = 393, 212 females). FBA was also compared with DTI, free-water corrected (FW)-DTI and diffusion kurtosis imaging (DKI).