Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. [5] FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling , and is also central to the decision for a pre adipocyte to commit ...

Dec 25, 2024 · FOXO1 (Forkhead Box O1) is a Protein Coding gene. Diseases associated with FOXO1 include Rhabdomyosarcoma 2 and Diffuse Large B-Cell Lymphoma. Among its related pathways are IL-9 Signaling Pathways and FOXO-mediated transcription.

Apr 10, 2024 · Our results show that overexpressing FOXO1 can increase the antitumour activity of human CAR T cells, and highlight memory reprogramming as a broadly applicable approach for optimizing...

Jan 15, 2018 · In periodontal mesenchymal stem cells (PDLSCs) from periodontitis patients, lncRNA and miR-182 suppress each other and form a network to regulate FOXO1. FOXO1 promotes the bone formation and differentiation of PDLSCs by competing with TCF-4 for β-catenin and the inhibition of the canonical Wnt pathway [47].

Here we give an overview of most recent findings regarding the regulation and function of FoxO1, its potential role in human diseases and useful animal models for functional studies on FoxO1.

Forkhead box transcription factor O1 (FoxO1) is an important member among the forkhead box transcription factor family. Through directly binding to the promoter regions of downstream target genes, FoxO1 is implicated in cell proliferation, apoptosis, …

Apr 10, 2024 · Here we show that overexpression of FOXO1 promotes a stem-like phenotype in CAR T cells derived from either healthy human donors or patients, which correlates with improved mitochondrial...

FOXO1 regulates wound-healing responses in human gingival fibroblasts. FOXO1 promotes cancer cell growth through MDM2-mediated p53 degradation. An extensive analysis of the prognostic and immune role of FOXO1 in various types of cancer. FoxO1 promotes ovarian cancer by increasing transcription and METTL14-mediated m[6]A modification of SMC4.

Foxo1 is essential for naive T cell homeostasis via its regulation of IL-7Rα. Foxo proteins regulate many aspects of effector T cell differentiation and memory responses. Foxo1 and Foxo3 directly activate the expression of Eomes, thereby control effector versus memory functional fate by regulating T-bet and Eomes expression.

Jan 10, 2020 · FoxO1 is a conserved transcription factor involved in energy metabolism. It is tightly regulated by modifications on its mRNA and protein and responds to environmental nutrient signals. FoxO1 controls the transcription of downstream genes mediating metabolic regulation.