DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found on viruses, bacteria and fungi.

DC-SIGN is a prototype C-type lectin organized in microdomains, which have their role as pathogen recognition receptors in sensing microbes. Although the integrin LFA-1 is a counter-receptor for both ICAM-2 and ICAM-3 on DC, DC-SIGN is …

DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin, where ICAM is intercellular adhesion molecule) is a recently described mannose-specific C-type lectin expressed by dendritic cells. Dendritic cells are potent antigen-presenting cells capable of activating T-lymphocytes.

DC-SIGN recognizes carbohydrates including high mannose glycans and fucose-containing glycans such as Lewis A, Lewis B, Lewis X and Lewis Y or fucosylated LacdiNAc (LDNF) that can be found on its ligands.

The dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is a type II C-type lectin whose expression is restricted to the most potent antigen-presenting cells (APCs), the dendritic cells (DCs). In recent years, ...

Sep 1, 2003 · HIV-1 targets DC-SIGN to hide in DCs and for efficient transmission to T cells, as DC-SIGN functions as a trans-receptor that efficiently presents infectious virus to target T cells.

DC-SIGN and L-SIGN are C-type lectins that recognize carbohydrate structures present on viral glycoproteins and function as attachment factors for several enveloped viruses. DC-SIGN and L-SIGN enhance viral entry and facilitate infection of cells ...

Mar 3, 2000 · We discovered that instead of the common ICAM-3 receptors LFA-1 and αDβ2, a novel DC-specific C-type lectin, DC-SIGN, binds ICAM-3 with high affinity. DC-SIGN, which is abundantly expressed by DC both in vitro and in vivo, mediates transient adhesion with T cells.

Mar 3, 2000 · DC SIGN is a type II membrane protein with an external mannose-binding, C-type lectin domain. It was cloned from a placental library, through its capacity to bind the glycan-rich HIV-1 envelope in the absence of CD4 (Curtis et al. 1992), the classic virus receptor.

Jun 13, 2004 · Both the dendritic cell receptor DC-SIGN and the closely related endothelial cell receptor DC-SIGNR bind human immunodeficiency virus and enhance infection. However, biochemical and structural...