It encodes the most abundant extracellular inhibitor of cysteine proteases. It is found in high concentrations in biological fluids and is expressed in virtually all organs of the body (CST3 is a housekeeping gene). The highest levels are found in semen, …

Jun 1, 2017 · Cystatin C (CYS C, Cst3) is an endogenous cysteine protease inhibitor that plays neuroprotective roles in neurodegenerative diseases.

Dec 24, 2024 · CST3 (Cystatin C) is a Protein Coding gene. Diseases associated with CST3 include Cerebral Amyloid Angiopathy, Cst3-Related and Macular Degeneration, Age-Related, 11. Among its related pathways are Innate Immune System and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).

Cystatin C, first described in 1961 and formally named in 1984, is a non-glycosylated, basic protein encoded by the CST3 gene that is found in virtually all nucleated cells.

Several studies have linked polymorphisms within the human CysC encoding gene [CST3; localized on chromosome 20 (Abrahamson et al., 1989; Saitoh et al., 1989)] to an increased risk of developing AD (Bertram et al., 2007; Beyer et al., 2001; Cathcart et al., 2005; Crawford et al., 2000; Finckh et al., 2000; Goddard et al., 2004; Lin et al., 2003 ...

Changes in expression and secretion levels of cystatin C (CysC) in the brain in various neurological disorders and in animal models of neurodegeneration underscore a role for CysC in these conditions. A polymorphism in the CysC gene (CST3) is linked to increased risk for Alzheimer's disease (AD).

Mar 13, 2020 · Our previous case-control study demonstrated that the haplotype of 3 SNPs in CST3 gene (−82C/+4C/+148A) is related to lower plasma CST3 concentration and risk of severe cerebral white matter...

Jun 1, 2017 · Cystatin C (CYS C, Cst3) is an endogenous cysteine protease inhibitor that plays neuroprotective roles in neurodegenerative diseases. We aimed to explore the association of CYS C with Parkinson's disease (PD) models and investigate its involvement in the role of neurovascular units (NVUs) in PD neur …

Nov 18, 2007 · Using transgenic mice expressing human cystatin C (encoded by CST3), we show that cystatin C binds soluble amyloid-β peptide and inhibits cerebral amyloid deposition in amyloid-β precursor...

Sep 7, 2021 · Cystatin C (CST3) is an endogenous cysteine protease inhibitor, which is implicated in cerebral amyloid angiopathy (CAA). In CAA, CST3 is found to be aggregated. The purpose of this study is to investigate whether this aggregation could alter the activity of the protein relevant to the molecular pathology of CAA.